| 引用本文: | 徐伟良,詹怡飞,杨岚.NL-101-羟丙基倍他环糊精包合物的制备及其特性研究[J].中国现代应用药学,2017,34(11):1568-1571. |
| XU Weiliang,ZHAN Yifei,YANG Lan.Study on the Preparation of NL-101-hydroxypropylbetadex Inclusion Complex and its Characteristic[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(11):1568-1571. |
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| 摘要: |
| 目的 考察NL-101-羟丙基倍他环糊精包合物的制备方法。方法 采用冷冻干燥法制备NL-101-羟丙基倍他环糊精包合物，以NL-101包合率为指标，通过正交试验优化包合条件。结果 优化的工艺条件为搅拌速度100 r·min-1，搅拌温度10℃，搅拌时间30 min，NL-101：羟丙基倍他环糊精摩尔比为1：10，按此条件采用冷冻干燥法制备NL-101-羟丙基倍他环糊精包合物，采用X衍射分析和红外光谱法进行确认，表明冷冻干燥后得到了包合物。结论 NL-101与羟丙基倍他环糊精通过冷冻干燥法可形成包合物，按此工艺条件，NL-101-羟丙基倍他环糊精包合物的包合率>95%，同时包合物可提高NL-101的溶解度。 |
| 关键词: NL-101 羟丙基倍他环糊精 包合 包合率 冷冻干燥 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.11.015 |
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| Study on the Preparation of NL-101-hydroxypropylbetadex Inclusion Complex and its Characteristic |
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XU Weiliang, ZHAN Yifei, YANG Lan
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Hangzhou Minsheng Institutes for Pharma Research Co., Ltd., Hangzhou 311121, China
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| Abstract: |
| OBJECTIVE To study the preparation of NL-101-hydroxypropyl betacyclodextrin inclusion complex. METHODS The NL-101-hydroxypropylbetadex inclusion complex was prepared by freeze drying method and was optimized with inclusion ratio as index by orthogonal experiment. RESULTS The optimized conditions were 100 r·min-1 of stirring speed, 10℃ of stirring temperature, 30 min of stirring time, 1:10 of ratio of NL-101:hydroxypropyl betacyclodextrin confirmed by X-ray diffraction method and infrared spectroscopy. CONCLUSION NL-101-hydroxypropylbetadex inclusion complex can be effectively prepared with freeze drying method. And the inclusion with greater than 95% of the inclusion ratio is prepared. The solubility of NL-101 is increased when the durg was included by hydroxypropyl betacyclodextrin. |
| Key words: NL-101 NL-101-hydroxypropylbetadex inclusion complex inclusion ratio freeze drying |
