| 引用本文: | 杨茗钫,徐文炜,程晓华.齐墩果酸对氟伐他汀在大鼠体内药动学的影响[J].中国现代应用药学,2017,34(6):811-814. |
| YANG Mingfang,XU Wenwei,CHENG Xiaohua.Effect of Oleanolic Acid on the Pharmacokinetics of Fluvastatin in Rats[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(6):811-814. |
|
| 摘要: |
| 目的 探讨齐墩果酸对氟伐他汀在大鼠体内的药动学影响。方法 将16只健康大鼠随机分为单药组（5.0 mg·kg-1氟伐他汀）和联合用药组（5.0 mg·kg-1氟伐他汀+60 mg·kg-1齐墩果酸），单药组和联合用药组分别灌胃空白溶剂和齐墩果酸5 d，每天1次，第6天2组均给予氟伐他汀灌胃。给药后不同时间点采血，LC-MS测定大鼠体内血药浓度，比较2组间主要的药动学参数。结果 与单药组比较，联合用药组氟伐他汀主要药动学参数Cmax、AUC0-t显著上升，组间比较差异具有统计学意义（P<0.05）。结论 联合应用齐墩果酸可能影响大鼠体内氟伐他汀的药动学特性。 |
| 关键词: 氟伐他汀 齐墩果酸 药动学 高效液相色谱质谱联用 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.06.005 |
| 分类号: |
| 基金项目:“重大新药创制”国家科技重大专项（2011ZX09302-007-03）；江西省青年科学基金计划项目（20142BAB215019）；江西省卫生计生委科技计划项目（20175136） |
|
| Effect of Oleanolic Acid on the Pharmacokinetics of Fluvastatin in Rats |
|
YANG Mingfang1, XU Wenwei2, CHENG Xiaohua1
|
|
1.The First Affiliated Hospital of Nanchang University, Nanchang 330006, China;2.Institute of Clinical Pharmacology of Nanchang University, Nanchang 330006, China
|
| Abstract: |
| OBJECTIVE To explore the effect of oleanolic acid(OA) on the metabolism of fluvastatin in rats. METHODS Sixteen health rats were randomly divided into two groups: the single group(fluvastatin 5.0 mg·kg-1) and the combined group(fluvastatin 5.0 mg·kg-1+OA 60 mg·kg-1). The single group were administrated with blank solution while the combined group were administrated with the same volume of OA, the administration period of 5 d. At the sixth day, both groups were administrated with fluvastatin, plasma concentrations of fluvastatin were determined by LC-MS. The main pharmacokinetic parameters were calculated and compared. RESULTS The main pharmacokinetic parameters(Cmax, AUC0-t) of the combined group showed increased remarkably compared with the single group. Statistically significant difference was showed between groups(P<0.05). CONCLUSION OA can affect the pharmacokinetic parameters of fluvastatin in rats. |
| Key words: fluvastatin oleanolic acid pharmacokinetic LC-MS |
