| 引用本文: | 罗国良,汪洋,李华强,舒志恒,秦路平,郑承剑.牡荆子化学成分研究[J].中国现代应用药学,2017,34(6):794-799. |
| LUO Guoliang,WANG Yang,LI Huaqiang,SHU Zhiheng,Qin Luping,ZHENG Chengjian.Chemical constituents from fruits of Vitex negundo L. var. cannabifolia[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(6):794-799. |
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| 摘要: |
| 目的 研究牡荆属植物牡荆Vitex negundo L. var. cannabifolia果实的化学成分。方法 采用反复硅胶柱层析、MCI、凝胶柱层析、制备液相色谱法及重结晶等方法，对牡荆子提取物进行分离纯化，根据波谱数据结合理化性质解析得到化合物的结构。结果 从牡荆子果实80%乙醇提取物中共分离鉴定22个化合物，从牡荆子石油醚部位分离、鉴定5个化合物，从二氯甲烷部位分离、鉴定17个化合物。其中，9个木脂素类化合物，3个二萜类化合物，1个三萜类化合物，6个黄酮类化合物，3个酚酸类化合物。结论 4β-羟基泡桐素、和厚朴酚与无羁萜为首次从该植物中分离得到。5,7,2',5'-四羟基黄酮为首次从该属植物中分离得到。 |
| 关键词: 牡荆子 4β-羟基泡桐素 和厚朴酚 5,7,2',5'-四羟基黄酮 无羁萜 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.06.002 |
| 分类号: |
| 基金项目:国家自然科学基金资助项目（81473328）；上海市科委科技创新行动计划（14401902500，16401901500） |
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| Chemical constituents from fruits of Vitex negundo L. var. cannabifolia |
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LUO Guoliang1, WANG Yang1, LI Huaqiang2, SHU Zhiheng2, Qin Luping2, ZHENG Chengjian2
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1.Zhejiang Intec Group Company Limited, Hangzhou 310015, China;2.Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
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| Abstract: |
| OBJECTIVE To study the chemical constituents from the fruits of Vitex negundo L. var. cannabifolia. METHODS The chemical constituents were isolated and purified by chromatography on silica gel, ODS, MCI, Sephadex LH-20 columns, RP-HPLC and recrystallization. The structures were identified on the basis of physicochemical properties and spectral data analyses. RESULTS A total of 22 compounds were separated and identified from the 80% ethanol extract of Vitex negundo L. var. cannabifolia fruits, with 5 compounds from petroleum ether fraction and 17 compounds from dichloromethane fraction, including 9 lignans, 3 diterpenoids, 1 triterpenoid, 6 flavonoids and 3 phenolic acids compounds. CONCLUSION 4β-Paulownin, hinokiol and friedelin are isolated from this plant for the first time. 5,7,2',5'-Tetrahydroxyflavone is obtained from this genus for the first time. |
| Key words: fruits of Vitex negundo L. var. cannabifolia 4β-paulownin hinokiol 5,7,2',5'-tetrahydroxyflavone friedelin |
