| 引用本文: | 孙浩,陈闯,菅凌燕,肇丽梅.多黏菌素B局部给药治疗泛耐药鲍曼不动杆菌神经系统感染[J].中国现代应用药学,2017,34(5):737-739. |
| SUN Hao,CHEN Chuang,JIAN Lingyan,ZHAO Limei.Effect of Using Polymyxin B by Local Medication on Xdr-Acinetobacter Baumannii Infections of the Nervous System[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(5):737-739. |
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| 摘要: |
| 目的 探讨泛耐药鲍曼不动杆菌神经系统感染的治疗策略。方法 结合临床药师亲身参与的1例泛耐药鲍曼不动杆菌神经系统感染的治疗，介绍多黏菌素B在治疗中的合理应用。结果 临床药师推荐通过多黏菌素B局部给药方式，加强局部组织药物浓度，提高泛耐药鲍曼不动杆菌治疗效果。同时，在多黏菌素B的应用剂量、途径、监护等多方面提供了合理建议。患者感染最终得以控制，未出现肾毒性和神经毒性反应。结论 多黏菌素B的局部用药为泛耐药鲍曼不动杆菌神经系统感染治疗提供了新思路。 |
| 关键词: 多黏菌素B 泛耐药 鲍曼不动杆菌 神经系统感染 临床药师 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.05.024 |
| 分类号: |
| 基金项目:无 |
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| Effect of Using Polymyxin B by Local Medication on Xdr-Acinetobacter Baumannii Infections of the Nervous System |
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SUN Hao, CHEN Chuang, JIAN Lingyan, ZHAO Limei
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Pharmacy Department, Shengjing Hospital of China Medical University, Shenyang 110004, China
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| Abstract: |
| OBJECTIVE To discuss extensively drug resistant(XDR)-Acinetobacter baumannii infection treatment strategy of the nervous system. METHODS Combining with a case of XDR-Acinetobacter baumannii therapy of nervous system infection, to introduce reasonable application of polymyxin B. RESULTS According to the consensus, the clinical pharmacist recommended to use polymyxin B by local medication to strengthen the local tissue drug concentration and improve the effect of XDR-Acinetobacter baumannii treatment. At the same time, the clinical pharmacist provided the reasonable suggestions in many aspects, such as in the application of polymyxin B dosage, ways, monitoring and so on for clinician. In the end, the infection was under control without renal toxicity and nerve toxicity reaction. CONCLUSION Using polymyxin B by local medication provides a new way of thinking of XDR-Acinetobacter baumannii infections of the nervous system. |
| Key words: polymyxin B XDR Acinetobacter baumannii nervous system infection clinical pharmacists |
