| 引用本文: | 遵倩,邱利焱.温敏聚合物自组装纳米粒子在抗肿瘤药物递送中的应用[J].中国现代应用药学,2017,34(6):913-922. |
| ZUN Qian,QIU Liyan.Nanoparticles Self-assembled by Thermoresponsive Polymers for Anticancer Drug Delivery[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(6):913-922. |
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| 摘要: |
| 作为抗肿瘤治疗的主要手段，化疗最大的缺陷在于化疗药物缺乏肿瘤靶向性，易对正常组织产生高毒性，并导致治疗效果不理想。为解决这一问题，越来越多的聚合物纳米载体被用于递送抗肿瘤药物，包括对温度刺激能作出响应的温敏聚合物自组装纳米载体。本文综述了近年来温敏聚合物自组装载体及其纳米粒子的研究进展，并介绍了其在抗肿瘤药物递送中的应用。 |
| 关键词: 温敏聚合物 自组装 胶束 囊泡 药物递送 抗肿瘤 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.06.029 |
| 分类号:R |
| 基金项目:国家自然科学基金资助项目（81673384） |
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| Nanoparticles Self-assembled by Thermoresponsive Polymers for Anticancer Drug Delivery |
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ZUN Qian, QIU Liyan
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Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
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| Abstract: |
| As one of the main means for cancer therapy, the biggest drawback of chemotherapy is that most of chemotherapeutics can't target tumor, resulting in high toxicity to normal tissues and unsatisfied treatment effect. In order to overcome this problem, a growing number of polymeric nanocarriers have been studied to deliver antineoplastic drugs, including those self-assembled to nanoparticles showing a change in physic-chemical properties in response to a temperature stimulus. This paper summarize the recent research progress of thermoresponsive polymers and their self-assembled nanoparticles, and introduce their application in anticancer drug delivery. |
| Key words: thermoresponsive polymer self-assemble micelle polymersome drug delivery anticancer |
