| 摘要: |
| 黄芪甲苷是黄芪的主要活性成分，具有众多的生物活性，如抗神经退行性疾病（阿尔兹海默病、帕金森）、抗应激、抗纤维化、抗病毒、抗炎等。查阅国内外文献发现抗细胞凋亡作用与多种疾病密切相关，本文从细胞凋亡产生的重要途径如死亡受体途径、线粒体途径、内质网途径、PI3K/Akt途径、MAPK途径等多个方面对黄芪甲苷抗凋亡作用机制进行综述，为黄芪甲苷在抗细胞凋亡的相关研究提供参考。 |
| 关键词: 黄芪甲苷 抗凋亡 作用机制 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.05.035 |
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| Process of the Anti-apoptotic Mechanism of Astragaloside Ⅳ |
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ZHOU Qin
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Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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| Abstract: |
| Astragaloside Ⅳ is a main active constituent of the Astragalus membranaceus, it has many biological activities, such as anti-neurodegenerative disease(AD, Parkinson's disease), anti-stress, anti-fibrotic, anti-virus, anti-inflammatory, etc. The anti-apoptosis effect is closely associated with many diseases. In this paper, the mechanisms of Astragaloside Ⅳ on anti-apoptosis effect related to many effects, such as death receptor pathway, mitochondrion pathway, endoplasmic reticulum pathway, PI3K/Akt pathway, MAPK pathway were reviewed, aiming at providing a reference about astragaloside Ⅳ in anti-apoptosis effect of related research for people in the future. |
| Key words: astragaloside Ⅳ anti-apoptosis effect mechanism |
