| 引用本文: | 夏佳,姚慧,杜吕佩,陈红娟,席时东.保健品中一种新型他达拉非相关化合物的结构鉴定[J].中国现代应用药学,2017,34(8):1167-1170. |
| XIA Jia,YAO Hui,DU Lyupei,CHEN Hongjuan,XI Shidong.Structure Identification of a New Tadalafil Related Compound in Dietary Supplement[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(8):1167-1170. |
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| 摘要: |
| 目的 鉴定保健品中发现的一种新型他达拉非化合物的结构。方法 通过高效液相色谱-二极管阵列检测器联用筛查，发现一种补肾壮阳类保健食品中添加了一种他达拉非类化合物。经过制备液相提纯后，得到目标化合物，用高效液相色谱-四级杆/飞行时间质谱获得相对分子质量和结构碎片。结合核磁共振氢谱和碳谱及相关文献数据，鉴定出该化合物的结构。结果 在保健品中发现添加了一种新型的他达拉非类化合物二乙氨基前他达拉非。结论 该化合物不在现有补肾壮阳类中成药检验标准的11种目标化合物范围内，有必要加以研究。 |
| 关键词: 保健品 他达拉非相关化合物 结构鉴定 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.08.021 |
| 分类号:R917.101 |
| 基金项目: |
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| Structure Identification of a New Tadalafil Related Compound in Dietary Supplement |
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XIA Jia1, YAO Hui1, DU Lyupei2, CHEN Hongjuan3, XI Shidong1
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1.Ningbo Institute for Drug Control, Ningbo 315048, China;2.College of Phamacy, Shandong University, Jinan 250000, China;3.Nanjing University State Key Laboaratory of Pharmaceutical Biotechnology, Nanjing 210046, China
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| Abstract: |
| OBJECTIVE To identify a new tadalafil related compound adulterated in a dietary supplement. METHODS A new tadalafil related compound was detected in a routine screening for compounds adulterated in a dietary supplement by HPLC-DAD. The target compound was isolated by preparative high performance liquid chromotography. Its molecular weight and structural fragments were obtained by HPLC-MS/MS. 1H-NMR spectrum and 13C-NMR spectrum were obtained by means of nuclear magnetic resonance. Its structure was identified by analysis of all these data and related textual comparison. RESULTS A new tadalafil related compound named diethylaminopretadalafil was detected in a dietary supplement. CONCLUSION The compound is not in the current inspection standard lists, which includes 11 target compounds. It is necessary to study this compound. |
| Key words: dietary supplement tadalafil related compound structure identification |
