| 引用本文: | 胡帆,李煜,陈悦.甲磺酸多沙唑嗪多晶型表征研究[J].中国现代应用药学,2017,34(2):242-246. |
| HU Fan,LI Yu,CHEN Yue.Characterization Study of Polymorphism of Doxazosin Mesylate[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(2):242-246. |
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| 摘要: |
| 目的 研究甲磺酸多沙唑嗪晶型特征，为多晶型研究提供实验依据。方法 采用X射线粉末衍射法（XRPD）、差示扫描量热法（DSC）、热重法（TG）、红外光谱分析（IR）、拉曼光谱分析及溶解性试验对甲磺酸多沙唑嗪晶A型与晶H型进行多晶型研究。结果 获得甲磺酸多沙唑嗪晶A型与晶H型的表征图谱。结论 X射线粉末衍射法、差示扫描量热法与热重法可用于定性区分甲磺酸多沙唑嗪晶A型与晶H型，晶H型溶解度性质优于晶A型。 |
| 关键词: 甲磺酸多沙唑嗪 晶型表征 粉末X射线衍射 热分析 红外光谱 拉曼光谱 溶解性试验 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.02.019 |
| 分类号:R284.1；R917.101 |
| 基金项目: |
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| Characterization Study of Polymorphism of Doxazosin Mesylate |
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HU Fan, LI Yu, CHEN Yue
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Zhejiang Institute for Food and Drug Control, Hangzhou 310052, China
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| Abstract: |
| OBJECTIVE To study the characterization of doxazosin mesylate forms and provide polymorphic research material.METHODS Characterization spectrum of form A and form H of doxazosin mesylate were detected by X-ray powder diffraction(XRPD), differential scanning calorimeter(DSC), thermo-gravimetric analysis(TG), infrared radiation(IR), Raman spectra analysis and dissolution test.RESULTS Characterization figures of form A and form H were obtained.CONCLUSION Form A and form H show difference in XRPD, DSC and TG patterns, form H has better performance in dissolution test. |
| Key words: doxazosin mesylate polymorphic characterization X-ray powder diffraction thermal analysis infrared radiation Raman spectra dissolution test |
