| 引用本文: | 高干,周艺,刘杰,李程,江相兰,牟杰.单酚类抗氧化剂及其衍生物的抗肿瘤作用及机制[J].中国现代应用药学,2017,34(4):613-617. |
| GAO Gan,ZHOU Yi,LIU Jie,LI Cheng,JIANG Xianglan,MOU Jie.Antineoplastic Activities and Its Possible Mechaniams of the Monophenolic Antioxidants[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(4):613-617. |
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| 摘要: |
| 目的 筛选单酚类抗氧化剂衍生物以发现新型抗肿瘤药物。方法 参考国内外相关文献，对单酚类抗氧化剂及其衍生物的的抗肿瘤作用的机制和构效关系进行综述。结果 结构修饰后的单酚类衍生物比单酚抗氧化剂的抗肿瘤活性及稳定性明显提高。结论 通过对抗氧化活性较高的单酚类衍生物构效关系进行研究，将有可能为临床提供更多的安全、有效药物。 |
| 关键词: 单酚类抗氧化剂 抗肿瘤 构效关系 机制 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.04.031 |
| 分类号:R284.1；R917.101 |
| 基金项目:地方高校国家级大学生创新创业训练计划项目（201510313028）；江苏省高等学校大学生创新创业训练计划立项项目（201510313028Z）；江苏省新药研究与临床药学重点实验室主任基金（ZR-XY201403）；徐州医学院药学院教育教学改革课题（2015-18） |
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| Antineoplastic Activities and Its Possible Mechaniams of the Monophenolic Antioxidants |
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GAO Gan, ZHOU Yi, LIU Jie, LI Cheng, JIANG Xianglan, MOU Jie
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College of Pharmacy, Xuzhou Medical University, Xuzhou 221000, China
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| Abstract: |
| OBJECTIVE To explore the novel antineoplastic drugs by screening the monophenolic derivatives with high antioxidant activity. METHODS According to the literature in recent years, monophenolic antioxidants and their derivatives were discussed about the clinical research and mechanism. RESULTS The derivatives of monophenolic antioxidant were more stable or more effective than monophenolic antioxidant in antineoplastic activity. CONCLUSION As the research of the structure-activity relationship moves along, it will be possible to provide more safe and effective drugs for clinical through the modification of monophenolic antioxidants. |
| Key words: monophenolic compounds antineoplastic structure-activity relationship mechaniams |
