| 引用本文: | 蒋杰,石夏莹,张谊芳,王伶,沈男男.药学干预对肺结核合并糖尿病患者临床治疗影响的对照研究[J].中国现代应用药学,2017,34(2):288-292. |
| JIANG Jie,SHI Xiaying,ZHANG Yifang,WANG Ling,SHEN Nannan.Comparative Study on Effects of Pharmaceutical Intervention on Clinical Therapy for Pulmonary Tuberculosis Patients Complicated with Diabetes Mellitus[J].Chin J Mod Appl Pharm(中国现代应用药学),2017,34(2):288-292. |
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| 摘要: |
| 目的 评价药学干预对肺结核合并糖尿病患者临床治疗的影响。方法 采用前瞻性对照研究方法，入组肺结核合并糖尿病患者124例，随机分为未干预组（n=61）和干预组（n=63）。干预组由临床药师主导药学干预过程。比较2组患者的住院花费、治疗效果、药品不良事件发生率、用药依从性和患者满意度的差异。结果 研究期间，临床药师共提出药学建议89例次，其中76例次（85.39%）被临床完全采纳。与未干预组相比，干预组的人均住院费用和药品费用均有所下降且差异有统计学意义（P<0.05）。干预组的痰菌转阴率、病灶吸收率、空洞闭合率和血糖控制达标率均优于未干预组，差异有统计学意义（P<0.05）。药学干预使患者的用药依从性、药学服务满意度显著提高，药品不良事件发生率显著降低，差异均有统计学意义（P<0.01），但对平均住院天数的影响差异无显著性。结论 临床药师对肺结核合并糖尿病的住院患者实施全程化的药学干预，可促进药物合理使用，降低治疗费用，改善患者的治疗效果、用药依从性和满意度，也为临床药师参与临床慢病用药管理提供依据。 |
| 关键词: 药学干预 肺结核 糖尿病 临床药师 对照研究 |
| DOI：10.13748/j.cnki.issn1007-7693.2017.02.030 |
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| Comparative Study on Effects of Pharmaceutical Intervention on Clinical Therapy for Pulmonary Tuberculosis Patients Complicated with Diabetes Mellitus |
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JIANG Jie, SHI Xiaying, ZHANG Yifang, WANG Ling, SHEN Nannan
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Department of Clinical Pharmacy, Shaoxing Municipal Hospital, Shaoxing 312000, China
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| Abstract: |
| OBJECTIVE To evaluate the effects of pharmaceutical intervention on clinical therapy for pulmonary tuberculosis patients complicated with diabetes mellitus.METHODS Used prospective to control study, a total of 124 patients with pulmonary tuberculosis complicated by diabetes mellitus were randomly divided into the no-intervention group(n=61)and the intervention group(n=63). Clinical pharmacists participated in the programs of pharmaceutical intervention in the intervention group. Then the costs, the treatment efficiency, the incidence rate of adverse drug events, the medication compliance and the satisfaction were compared in 2 group.RESULTS The pharmacist carried out 89 recommendations for patients, and 76 (85.39%) of the recommendations were well accepted by the physicians. Compared with the no-intervention group, total costs for per person and drug costs were respectively significantly lower in the intervention group(P<0.05). The sputum negative conversion rate, lesions absorption rate, cavity closure rate and glucose control rate in intervention group were significantly higher than those of the no-intervention group(P<0.05). After pharmaceutical intervention, the drug adherence outstanding rate and pharmacy service satisfaction were significantly better than those in the no-intervention group, whereas the incidence rate of adverse drug events was quite lower (P<0.01). However, there was no significant difference in the average hospitalization time between the no-intervention group and the intervention group.CONCLUSION The whole course pharmaceutical intervention for the pulmonary tuberculosis patients complicated with diabetes mellitus can not only improve the rational use of drugs, the medication compliance, and the satisfaction, and reduce the hospitalization costs, but also provide a basis for the participation in chronic diseases management of clinical pharmacists. |
| Key words: pharmaceutical intervention pulmonary tuberculosis diabetes mellitus clinical pharmacists comparative study |
