| 引用本文: | 邵吕,高东萍,邵燕燕,郑旦.E-钙黏蛋白和波形蛋白表达与非小细胞肺癌铂类药物疗效相关性研究[J].中国现代应用药学,2016,33(12):1592-1597. |
| SHAO Lyu,GAO Dongping,SHAO Yanyan,ZHENG Dan.Correlation of E-cadherin and Vimentin Expression with Prognosis of Non-small-cell Lung Cancer and Sensitivity to Platinum-based Chemotherapy[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(12):1592-1597. |
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| 摘要: |
| 目的 探索上皮间质化因子E-钙黏蛋白和波形蛋白表达与非小细胞肺癌铂类药物疗效相关性。方法 回顾性收集2008年1月—2012年12月浙江省余姚市人民医院诊断为非小细胞肺癌、采用含铂方案治疗的患者资料及病理组织标本，以免疫组织化学染色法检测E-钙黏蛋白和波形蛋白表达，评价E-钙黏蛋白和波形蛋白表达与NSCLC临床特征的相关性，并以Kaplan-Meier生存曲线和COX回归风险比例模型评价E-钙黏蛋白和波形蛋白表达与NSCLC含铂方案治疗效果的相关性。结果 共99例NSCLC患者纳入研究，肿瘤组织中E-钙黏蛋白和波形蛋白表达存显著负相关（P<0.001，r=-0.410）。中晚期、低分化、有淋巴结转移的肺癌组织E-钙黏蛋白的阳性率降低，波形蛋白阳性率增高。E-钙黏蛋白表达阳性患者OS显著高于阴性患者（中位OS 31 vs 21月，HR 0.533，95% CI：0.322~0.882，P=0.014），波形蛋白与OS无相关性。E-钙黏蛋白和波形蛋白表达与疾病进展时间无显著相关性（P>0.05）。结论 E-钙黏蛋白是一个有潜力的NSCLC铂类药物疗效的预测因子，这仍需进一步前瞻性研究验证。 |
| 关键词: 非小细胞肺癌 E-钙黏蛋白 波形蛋白 |
| DOI：10.13748/j.cnki.issn1007-7693.2016.12.024 |
| 分类号:R284.1；R917.101 |
| 基金项目: |
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| Correlation of E-cadherin and Vimentin Expression with Prognosis of Non-small-cell Lung Cancer and Sensitivity to Platinum-based Chemotherapy |
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SHAO Lyu1, GAO Dongping2, SHAO Yanyan1, ZHENG Dan2
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1.Department of Clinical Pharmacy, Yuyao People's Hospital of Zhejiang Province, Yuyao 315400, China;2.Department of Pharmacy, Hangzhou Cancer Hospital, Hangzhou 310002, China
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| Abstract: |
| OBJECTIVE To investigate the correlations among E-cadherin and vimentin expression, epithelialmesenchymal transition factors, prognosis for non-small-cell lung cancer (NSCLC), and the sensitivity to platinum-based chemotherapy. METHODS Medical record data and pathological tissue specimens of NSCLC patients treated by platinum-based chemotherapy from January 2008 to December 2012 were collected retrospectively. Immunohistochemistry was performed to detect E-cadherin and vimentin expression and evaluate their correlation with clinical characteristics. Kaplan-Meier survival curve and Cox proportional hazards regression model were used to evaluate the correlation of E-cadherin and vimentin expression with prognosis of NSCLC and sensitivity to platinum-based chemotherapy. RESULTS A total of 99 NSCLC patients were enrolled in this study. A significant negative correlation was found between E-cadherin and vimentin expression in tumor tissues (P<0.001, r=-0.410). For lung cancer tissues with less differentiation and lymph node metastasis in middle and late stages, the positive rate of E-cadherin decreased, whereas the positive rate of vimentin increased. The OS of patients showing positive expression of E-cadherin was significantly higher than that of patients showing negative expression of E-cahedrin (median OS 31 vs 21 months, HR 0.533, 95%CI:0.322-0.882, P=0.014). However, vimentin was not correlated with OS. Moreover, E-cadherin and vimentin expression was not significantly correlated with disease progression(P>0.05). CONCLUSION E-cadherin can be used as a potential NSCLC prognostic factor but not as a predictive factor for the sensitivity of NSCLC platinum-based chemotherapy. Overall, the results need further investigation. |
| Key words: non-small-cell lung cancer E-cadherin vimentin |
