线粒体通透性转换孔在冠脉微循环障碍中的研究进展

朱侯勇; 黄进宇<sup>*</sup>

引用本文:	朱侯勇,黄进宇.线粒体通透性转换孔在冠脉微循环障碍中的研究进展[J].中国现代应用药学,2016,33(8):1092-1096.
	ZHU Houyong,HUANG Jinyu.Research Progress of Mitochondrial Permeability Transition Pore in the Coronary Artery Microcirculation Disturbance[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(8):1092-1096.

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线粒体通透性转换孔在冠脉微循环障碍中的研究进展
朱侯勇¹, 黄进宇²
1.浙江中医药大学，杭州 310053;2.杭州市第一人民医院，杭州 310006

摘要:

由于冠脉微循环障碍的发生机制比较复杂，临床上治疗冠脉微循环的药物疗效均未得到充分肯定，线粒体通透性转换孔(mitochondrial permeability transition pore，mPTP)的开放因会引起冠脉微循环细胞功能异常而成为当前治疗冠脉微循环障碍的热点研究靶标。本文就近几年国内外关于mPTP在冠脉微循环障碍中的作用研究进展进行简要讨论。

关键词: 冠脉微循环障碍细胞机制线粒体通透性转换孔

DOI：

分类号:R36

基金项目:冠心病微血管病变研究基金项目(LSG1501132)

Research Progress of Mitochondrial Permeability Transition Pore in the Coronary Artery Microcirculation Disturbance

ZHU Houyong¹, HUANG Jinyu²

1.Zhejiang Chinese Medical University, Hangzhou 310053, China;2.Hangzhou First People’s Hospital, Hangzhou 310006, China

Abstract:

Due to the mechanism of coronary artery microcirculation disturbance is complicated, the drug efficacy of clinical treatment of coronary microcirculation has not been fully affirmed. The open of mitochondrial permeability transition pore (mPTP) which causes coronary microcirculation dysfunction of cells become the hotspot research targets for the treatment of coronary microcirculation dysfunction. In this review, the lastest research progress of mPTP in the coronary artery microcirculation disturbance is briefly discussed.

Key words: coronary artery microcirculation disturbance cellular mechanism mitochondrial permeability transition pore