| 引用本文: | 金银秀,王玉新,石雷,潘万贵,游锦晨,李姿生.苯扎贝特纳米结构脂质载体的制备及质量评价[J].中国现代应用药学,2016,33(12):1526-1528. |
| JIN Yinxiu,WANG Yuxin,SHI Lei,PAN Wangui,YOU Jinchen,LI Zisheng.Preparation and Quality Evaluation of Bezafibrate Nanostructured Lipid Carriers[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(12):1526-1528. |
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| 摘要: |
| 目的 制备苯扎贝特纳米结构脂质载体（bezafibrate nanostructured lipid carriers，BZF-NLC），并对其进行质量评价。方法 采用熔融-乳化法制备BZF-NLC，正交试验筛选最优处方。使用扫描电镜观察BZF-NLC形态，激光粒径测定仪测定Zeta电位、粒径及分布，葡聚糖柱层析法测定包封率。结果 按优化条件制备的BZF-NLC为类球形粒子，平均粒径为（127.6±3.16）nm，多分散系数为0.191±0.02，粒度分布均匀，Zeta电位为（-28.4±0.7）mV，包封率为（94.28±1.09）%，体外释药具有缓释特征。结论 熔融-乳化法制备的BZF-NLC具有较好的理化性质，有一定的缓释作用。 |
| 关键词: 苯扎贝特 纳米结构脂质载体 制备 质量评价 |
| DOI：10.13748/j.cnki.issn1007-7693.2016.12.009 |
| 分类号:R944.1 |
| 基金项目:浙江省自然科学基金（LY14E050001）；浙江省教育厅一般科研项目（Y201432771）；台州职业技术学院博士后科研启动基金项目（2016BSH01）；台州职业技术学院一般课题（2016YB04） |
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| Preparation and Quality Evaluation of Bezafibrate Nanostructured Lipid Carriers |
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JIN Yinxiu, WANG Yuxin, SHI Lei, PAN Wangui, YOU Jinchen, LI Zisheng
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Chemical Pharmaceutical Research Institute, Taizhou Vocational Technical College, Taizhou 318000, China
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| Abstract: |
| OBJECTIVE To prepare bezafibrate nanostructured lipid carriers(BZF-NLC) and evaluate the quality. METHODS BZF-NLC was prepared by melt-emulsification method, and the optimal prescription was screened by orthogonal experiment. The morphology of BZF-NLC was observed by scanning electron microscope. Zeta potential, particle size and distribution were determined by granulometer. The entrapment efficiency was determined by Sephadex gel column chromatography. RESULTS BZF-NLC prepared under optimum conditions was approximately spherical with average particle size of (127.6±3.16) nm, PDI of 0.191±0.02, which were distributed evenly, and zeta potential of (-28.4±0.7)mV, encapsulation efficiency of (94.28±1.09)%, respectively. The profiles of BZF-NLC in vitro release had the features of sustainedrelease. CONCLUSION It shows that there are good physicochemical properties of BZF-NLC prepared by melt-emulsification method, and had a certain degree of sustained-release effect. |
| Key words: bezafibrate nanostructured lipid carriers preparation quality evaluation |
