| 引用本文: | 李育林,赵恒立,司文涛,李晓玲,汪海玥.五藤冲剂联合甲氨蝶呤治疗类风湿关节炎的临床研究[J].中国现代应用药学,2016,33(12):1570-1573. |
| LI Yulin,ZHAO Hengli,SI Wentao,LI Xiaoling,WANG Haiyue.Clinical Curative Effects Observation of Wuteng Chongji and Methotrexate in the Treatment of Rheumatoid Arthritis[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(12):1570-1573. |
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| 摘要: |
| 目的 观察自拟五藤冲剂联合甲氨蝶呤治疗类风湿关节炎的临床疗效及安全性。方法 将102例类风湿关节炎患者随机分为治疗组52例，观察组50例，观察组口服甲氨蝶呤片，治疗组在观察组基础上加口服自拟五藤冲剂，疗程12周，观察治疗前后患者的症状、体征及实验室相关指标的变化。结果 治疗组总有效率96.00%，观察组总有效率81.63%，二者比较有统计学差异（P<0.05）；治疗后两组在压痛关节数、压痛指数、肿胀指数、肿胀关节数、DAS28评分、CRP、晨僵时间、握力、HAQ评分方面均有统计学差异（P<0.05或P<0.01），在VAS评分、ESR方面无统计学差异（P>0.05）。结论 自拟五藤冲剂联合甲氨蝶呤治疗类风湿关节炎可显著改善患者症状、体征及炎性指标，显著优于单用甲氨蝶呤。 |
| 关键词: 五藤冲剂 类风湿关节炎 血沉 C反应蛋白 |
| DOI：10.13748/j.cnki.issn1007-7693.2016.12.019 |
| 分类号: |
| 基金项目:烟台市科技发展计划项目（2012093） |
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| Clinical Curative Effects Observation of Wuteng Chongji and Methotrexate in the Treatment of Rheumatoid Arthritis |
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LI Yulin, ZHAO Hengli, SI Wentao, LI Xiaoling, WANG Haiyue
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Yantai Hospital of Traditional Chinese Medicine, Yantai 264000, China
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| Abstract: |
| OBJECTIVE To observe the clinical curative effects and safety of Wuteng Chongji and methotrexate in the treatment of rheumatoid arthritis. METHODS The 102 cases of rheumatoid arthritis patients were randomly divided into treatment group(52 cases) and observation group(50 cases). Observation group oral methotrexate tablets, treatment group in the observation group on the basis of the oral Wuteng Chongji, and the course of treatment was 12 weeks observed before and after treatment in patients with symptoms, signs and laboratory indicators of change. RESULTS In the treatment group, the total effective rate was 96.00%. In the observation group, the total efficiency of 81.63%, there was significant difference between two groups(P<0.05). After treatment, in the two groups, the tender joint number, tenderness index, swelling index, swollen joint count, DAS28, CRP, time of morning stiffness, grip strength, HAQ score had significant difference(P<0.05 or P<0.01), the VAS score, ESR had no statistical difference(P>0.05). CONCLUSION Wuteng Chongji and methotrexate in the treatment of rheumatoid arthritis can significantly improve symptoms, signs and inflammatory index. They are better than single use of methotrexate tablets. |
| Key words: Wuteng Chongji rheumatoid arthritis ESR C reaction protein |
