| 引用本文: | 李楠楠,孟宪生,包永睿,王帅,孔晔.木蝴蝶挥发性成分体外抗肿瘤活性评价及化学成分研究[J].中国现代应用药学,2016,33(11):1361-1365. |
| LI Nannan,MENG Xiansheng,BAO Yongrui,WANG Shuai,KONG Ye.In Vitro Antitumor Activity and Chemical Analysis of Oroxyli Semen Volatile Constituents[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(11):1361-1365. |
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| 木蝴蝶挥发性成分体外抗肿瘤活性评价及化学成分研究 |
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李楠楠1, 孟宪生1,2,3,4, 包永睿1,2,3,4, 王帅1,2,3,4, 孔晔4
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1.辽宁中医药大学药学院, 辽宁 大连 116600;2.辽宁省组分中药工程技术研究中心, 辽宁 大连 116600;3.辽宁省现代中药研究工程实验室, 辽宁 大连 116600;4.辽宁中医药大学-安捷伦科技现代中医药多组学研究合作实验室, 辽宁 大连 116600
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| 摘要: |
| 目的 开展中药木蝴蝶挥发性成分的体外抗肝肿瘤作用研究，并在此基础上对其发挥抗肿瘤作用的木蝴蝶挥发性成分进行化学成分分析。方法 采用体外评价法考察木蝴蝶挥发性成分对人肝癌SMMC-7721细胞的抑制作用；采用GC-MS对木蝴蝶挥发性成分进行化学分析。结果 木蝴蝶挥发性成分对人肝癌SMMC-7721细胞具有明显的抑制作用；其挥发性成分鉴定出19种化合物，其中甾醇类、酮类化合物含量最高。结论 木蝴蝶挥发性成分是中药木蝴蝶发挥抗肿瘤作用的有效组分，其发挥药效的物质可能为烃类、苯类、甾醇类、酸类、酯类、酮类等化合物。 |
| 关键词: 木蝴蝶 挥发性成分 抗肿瘤 SMMC-7721 GC-MS |
| DOI：10.13748/j.cnki.issn1007-7693.2016.11.003 |
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| 基金项目:“十二五”重大新药创制科技重大专项(20132X09507005-004) |
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| In Vitro Antitumor Activity and Chemical Analysis of Oroxyli Semen Volatile Constituents |
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LI Nannan1, MENG Xiansheng1,2,3,4, BAO Yongrui1,2,3,4, WANG Shuai1,2,3,4, KONG Ye4
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1.School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China;2.Component Medicine Engineering Research Center of Liaoning Province, Dalian 116600, China;3.Liaoning Province Modern Chinese Medicine Research Engineerig Laboratory, Dalian 116600, China;4.Liaoning University of Traditional Chinese Medicine-Agilent Technologies Moden TCM and Multi-omics Research Collaboration Lab, Dalian 116600, China
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| Abstract: |
| OBJECTIVE To study the volatile constituents of traditional Chinese medicine (TCM) Oroxyli Semen's antitumor effect, and the basis to give the chemical analysis of it. METHODS Used in vitro method to carry out the effect on inhibition experiment of human liver cancer SMMC-7721 cells. For the anti liver tumor effective constituents in Oroxyli Semen by GC-MS analysis method, to carry out the chemical analysis study. RESULTS Oroxyli Semen volatile constituents had obvious inhibitory effect in human liver cancer SMMC-7721 cells. The volatile constituents were analysis by GC-MS method, deduced the 19 kinds of compounds, sterols, ketone compounds to the highest levels. CONCLUSION Oroxyli Semen volatile constituent is effective constituents, and it play to the role of antitumor, its efficacy constituents for hydrocarbons, benzene, sterol, acids, esters, ketones and other compounds. |
| Key words: Oroxyli Semen volatile constituents antitumor SMMC-7721 GC-MS |
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