| 引用本文: | 岳素荣,楼炜,贺吉香,王剑,沈腾.高乌甲素凝胶贴膏的流变学研究[J].中国现代应用药学,2016,33(7):900-904. |
| YUE Surong,LOU Wei,HE Jixiang,WANG Jian,SHEN Teng.Rheological Research of Lappaconitine Cataplasm[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(7):900-904. |
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| 摘要: |
| 目的 利用流变学对高乌甲素凝胶贴膏配方进行研究。方法 利用SMS物性测试仪测定胶强度，初步筛选高乌甲素凝胶贴膏的填充剂，然后利用旋转流变仪考察填充剂的用量和增黏剂对流变学的影响。结果 微粉硅胶增加基质胶强度最好，选作填充剂。流变学测定显示微粉硅胶可增加凝胶贴膏的弹性模量(elastic modulus，G′)和黏性模量(viscous modulus，G″)，对前者增加效果更好，最佳含量为2.5%；不同增黏剂均显著增加G″，而PVA对G′影响小，故选作增黏剂。采用中国药典2015年版第四部的黏附性检查法证实优化的高乌甲素凝胶贴膏黏附性能良好。结论 流变学参数是筛选凝胶贴膏处方的一种有用工具。 |
| 关键词: 高乌甲素 凝胶贴膏 流变学 黏弹性 弹性模量 黏性模量 |
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| 基金项目:浙江省重点科技创新团队计划(2013TD15) |
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| Rheological Research of Lappaconitine Cataplasm |
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YUE Surong1,2, LOU Wei3, HE Jixiang1, WANG Jian1, SHEN Teng2
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1.School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China;2.Key Laboratory of Smart Drug Delivery of the Ministry of Education, Departmentt of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China;3.The Third Affiliated Hospital of the Zhejiang Chinese Medical University, Hangzhou 310005, China
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| Abstract: |
| OBJECTIVE To research on the formulations of lappaconitine cataplasm by means of rheology METHODS The gel strength was measured by SMS Texture Analyser and the fillers of lappaconitine cataplasm were preliminary screen out. The rheology was measured by Malvern Rotational Rheometer and then the dosage of fillers and tackifiers were investigated and determined. RESULTS Aerosol could increase gel strength most remarkably and was designated as filler. Rheological measurement showed the aerosol could increase elastic modulus(G′) and viscous modulus(G″) simultaneously, but the former was more remarkable and the optimal content was 2.5%; All kinds of tackifiers could increase G″ remarkably. PVA have the least influence on G′ and was screened out as tackifier. The adhesiveness examination according to the 2015 edition of Chinese Pharmacopoeia (Part Ⅳ) verified the optimized lappaconitine cataplasm has good adhesive property. CONCLUSION Rheological parameters are useful tools for screening out the formulations of cataplasm. |
| Key words: lappaconitine cataplasm rheology viscoelasticity elasticity modulus viscidity modulus |
