影响氯吡格雷疗效的基因多态性研究进展

肖飞燕; 张伟; 周宏灏; 周淦<sup>*</sup>

引用本文:	肖飞燕,张伟,周宏灏,周淦.影响氯吡格雷疗效的基因多态性研究进展[J].中国现代应用药学,2016,33(3):375-380.
	XIAO Feiyan,ZHANG Wei,ZHOU Honghao,ZHOU Gan.Progress of Genetic Polymorphisms Affecting the Efficacy of Clopidogrel[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(3):375-380.

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影响氯吡格雷疗效的基因多态性研究进展
肖飞燕¹, 张伟¹, 周宏灏¹, 周淦^2,3
1.中南大学湘雅医院临床药理研究所，长沙 410008;2.中南大学湘雅医院，a.临床药理研究所;3.b.药物临床试验机构，长沙 410008

摘要:

氯吡格雷是临床上常用的抗血小板药物，它通过不可逆地结合于P2Y12受体血小板上，从而减少了二磷酸腺苷介导的血小板聚集。虽然氯吡格雷疗效显著，但是存在明显的个体差异。了解可能引起氯吡格雷个体差异的因素从而提高氯吡格雷的疗效，降低不良心血管事件的发现，是目前临床工作者关心的问题。本文综述了影响氯吡格雷药动学和药效学的基因多态性，旨为氯吡格雷临床个体化给药提供一定的参考依据。

关键词: 氯吡格雷基因多态性药动学药效学

DOI：

分类号:

基金项目:国家自然科学基金(81522048，81573511)；国家高技术研究发展计划(863计划，2012AA02A518)

Progress of Genetic Polymorphisms Affecting the Efficacy of Clopidogrel

XIAO Feiyan¹, ZHANG Wei¹, ZHOU Honghao¹, ZHOU Gan^2,3

1.Xiangya Hospital, Central South University, Department of Clinical Pharmacology, Changsha 410008, China;2.Xiangya Hospital, Central South University, a.Department of Clinical Pharmacology;3.b.National Institution of Drug Clinical Trial, Changsha 410008, China

Abstract:

Clopidogrel is a commonly antiplatelet drug used in clinically, reducing the adenosine diphosphate (ADP)-mediated platelet aggregation by binding to the platelet P2Y12 receptor irreversibly. Although clopidogrel has significant effect, there are obvious individual differences. Learning the factors that may cause clopidogrel individual differences to improve the effect of clopidogrel is an issue that clinicians concerns, thus to reduce adverse cardiovascular events. This paper reviews the impact of genetic polymorphisms to clopidogrel pharmacokinetics and pharmacodynamics, and aims to provide a reference for individual dose of clopidogrel in clinically.

Key words: clopidogrel gene polymorphism pharmacokinetics pharmacodynamics