| 引用本文: | 贾宝秀,谢云兰,李莉,王仁亮.利多卡因表面分子印迹聚合物的制备及其吸附特性研究[J].中国现代应用药学,2016,33(8):1030-1034. |
| JIA Baoxiu,XIE Yunlan,LI Li,WANG Renliang.Preparation of Lidocaine Nano Silica Surface Molecular Imprinted Polymers and Its Binding Characteristics[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(8):1030-1034. |
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| 摘要: |
| 目的 采用分子印迹技术制备利多卡因二氧化硅表面分子印迹聚合物，探究其吸附特性，用于选择性吸附、富集利多卡因。方法 利用分子印迹技术，以利多卡因为模板分子，通过溶胶-凝胶法制备利多卡因二氧化硅表面分子印迹聚合物，并通过静态吸附平衡试验、动态吸附试验、扫描电镜、红外光谱研究聚合物的吸附特性、结构及形貌特征。结果 与化学组成相同的非印迹聚合物相比，印迹聚合物具有良好的吸附性。结论 将该印迹聚合物用于选择性吸附、富集利多卡因是可行的。 |
| 关键词: 纳米二氧化硅 分子印迹 利多卡因 |
| DOI： |
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| 基金项目:山东省自然科学基金项目(ZR2013HL061)；泰安市科技发展计划(2015NS2124) |
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| Preparation of Lidocaine Nano Silica Surface Molecular Imprinted Polymers and Its Binding Characteristics |
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JIA Baoxiu, XIE Yunlan, LI Li, WANG Renliang
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College of Pharmaceutical, Taishan Medical University, Tai’an 271016, China
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| Abstract: |
| OBJECTIVE To prepare lidocaine nano silica surface molecular imprinted polymers using molecular imprinting technique, and explore its adsorption properties for selective adsorption and enrichment of lidocaine. METHODS A nano silica surface molecular imprinted polymer was prepared by sol-gel method, in which lidocaine was template molecule. Equilibrium binding experiment was used to investigate the adsorption dynamics, the binding ability to template molecule and the substrate selectivity. The Scatchard analysis was used to study that the MIPs’ binding characteristic to template molecule. RESULTS Compared with the same chemical composition of non imprinted polymer, the polymer had good adsorption. CONCLUSION Systematic study on recognition properties of nano silica surface molecular imprinted polymer is carried out. It is found that the imprinted polymer shows good binding characteristics to lidocaine. |
| Key words: nano silica molecular imprinted lidocaine |
