| 引用本文: | 朱社敏,谢珍,瞿霖吉,刘璐,匡荣.BCOP法评价染发类化妆品眼刺激性的研究[J].中国现代应用药学,2016,33(8):1000-1003. |
| ZHU Shemin,XIE Zhen,QU Linji,LIU Lu,KUANG Rong.Research on Eye Irritation of Hair Dyes by Using Bovine Corneal Opacity Permeability Test[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(8):1000-1003. |
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| 摘要: |
| 目的 尝试采用牛角膜混浊和渗透性试验 (bovine corneal opacity and permeability，BCOP)对染发类化妆品进行眼刺激性的评价。方法 通过对染发剂与牛角膜的接触时间、染发剂各组成成分、染发剂配制后存放时间等检测条件的摸索，尝试建立一套标准的BCOP法评价染发类化妆品眼刺激性的方法，并用该法对市售样品进行评价性检测。结果 染发剂与牛角膜接触时间与刺激性大小成正比；染发剂各组成成分的刺激性不同，其中作为氧化剂的组分(通常为B剂或2剂)均为无刺激性，染发剂中的A剂或1剂的刺激性各品种存在较大的差异；染发剂配制后存放一定时间，刺激性会下降。以配制后即刻给样，接触牛眼时间为10 min，对市场销售的13种染发类化妆品进行评价性检测，结果体外刺激得分为3.5~78.2，分类为轻微刺激性的有10种，中度刺激性的有1种，严重刺激性的有2种。结论 用BCOP法可以对染发类化妆品的眼刺激性进行评价。 |
| 关键词: 化妆品 染发剂 牛角膜 BCOP |
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| Research on Eye Irritation of Hair Dyes by Using Bovine Corneal Opacity Permeability Test |
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ZHU Shemin, XIE Zhen, QU Linji, LIU Lu, KUANG Rong
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Zhejiang Institute of Food and Drug Control, Hangzhou 310004, China
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| Abstract: |
| OBJECTIVE Try to evaluate the eye irritation of hair dyes by bovine corneal opacity and permeability(BCOP) test. METHODS Try to establish a standard method on eye irritation of hair dyes by using BCOP test, which was through the exploration of contact time between hair dyes and bovine cornea, the composing components of the hair dyes and the storage time after preparation of the hair dyes. RESULTS There was a positive correlation between contact time and the stimulation intensity; Each composing component showed different ocular irritation, oxidizer agent (generally was B agent or 2 agent) was non-irritation, while there was a great difference in the ocular irritation on A agent or 1 agent of different varieties; The ocular irritation of the prepared hair dyes was reduced after being placed for some time. 13 kinds of hair dyes products from market were selected to predict ocular irritation under the conditions that giving samples immediately when the hair dyes were prepared and the contract time with bovine was 10 min, in the experiments, the in vitro irritant score was 3.5-78.2, the results showed that the kinds of mild irritation were 10, moderate irritation was 1, severe irritation were 2. CONCLUSION BCOP method can be applied to predict ocular irritation of hair dyes. |
| Key words: cosmetic hair dyes corneal BCOP |
