| 引用本文: | 王小婷,蒋国政,王海滨,王凤霞,李艳华,盛尊来.乌梅肉提取物抗腹泻作用研究[J].中国现代应用药学,2016,33(4):407-410. |
| WANG Xiaoting,JIANG Guozheng,WANG Haibin,WANG Fengxia,LI Yanhua,SHENG Zunlai.Experimental Study on Anti-diarrheal Activity of Pulp of Mume Fructus Extraction[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(4):407-410. |
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| 摘要: |
| 目的 研究乌梅提取物抗腹泻作用，为临床应用提供依据。方法 通过蓖麻油致小鼠腹泻模型、小肠炭墨推进实验、大鼠肠腔积液实验，以腹泻抑制率、小肠推进率、肠腔积液体积为指标，研究乌梅提取物的抗腹泻作用。结果 乌梅水提物及水提醇沉提取物均具有抗腹泻作用，其中水提醇沉提取物的活性明显高于水提物(P<0.05)，显著抑制正常小鼠的小肠推进运动(P<0.05或0.01)，但对肠腔积液作用不显著。结论 乌梅提取物具有一定的抗腹泻作用，其抗腹泻机制可能与抑制小肠运动有关。 |
| 关键词: 腹泻 乌梅 腹泻抑制率 小肠推进率 肠腔积液 |
| DOI： |
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| 基金项目:黑龙江省教育厅科学技术研究项目(12531047) |
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| Experimental Study on Anti-diarrheal Activity of Pulp of Mume Fructus Extraction |
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WANG Xiaoting, JIANG Guozheng, WANG Haibin, WANG Fengxia, LI Yanhua, SHENG Zunlai
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College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
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| Abstract: |
| OBJECTIVE To study the anti-diarrheal activity of Pulp of Mume Fructus extraction. METHODS Anti-diarrheal activity of Mume Fructus extraction was evaluated using castor oil-induced diarrhea, charcoal meal transit and castor oil-induced enteropooling in different group mice or rats. RESULTS Mume Fructus extraction and its preliminary purified extraction both possessed anti-diarrheal property in mice and the latter was superior to the former. Although the preliminary purified extraction did not decreased the volume of castor oil-induced intestinal fluid secretion, it caused a dose-dependent decrease of gastrointestinal transit (P<0.05). CONCLUSION The findings of this study indicate that Mume Fructus extraction possesses anti-diarrhoeal property that related with decreasing gastrointestinal transit. |
| Key words: diarrhea Mume Fructus inhibition rate of diarrhea charcoal meal transit rate enteropooling |
