| 引用本文: | 朱佩君,柯沙沙,徐芳.百令胶囊对狼疮性肾炎患者IL-2、补体及感染率的影响[J].中国现代应用药学,2016,33(3):364-368. |
| ZHU Peijun,KE Shasha,XU Fang.Effect of Bailing Capsules on Interleukin-2, Complement and Infection Rate in Patients with Lupus Nephritis[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(3):364-368. |
|
| 摘要: |
| 目的 探讨百令胶囊对狼疮性肾炎(lupus nephritis，LN)患者白介素-2(interleukin-2，IL-2)、补体及感染率的影响。方法 将120例LN患者随机分成观察组和对照组，每组60例。2组常规治疗相同，观察组给予百令胶囊(每次1 g，每天3次)治疗，比较2组治疗12个月临床疗效、感染率、IL-2、补体C3及药物不良反应情况。结果 治疗12个月，与对照组相比，观察组IL-2、补体C3和血白蛋白显著升高，尿蛋白、尿红细胞和SLEDAI显著降低，差异均有统计学意义(P<0.05)。观察组有效率(88.33%)显著高于对照组(71.67%)，感染率(21.67%)显著低于对照组(45.00%)，差异均有统计学意义(P<0.05)。2组不良反应发生率比较，差异无统计学意义。结论 百令胶囊通过调节IL-2和补体C3水平提高LN的临床疗效，降低感染率，且不增加药物不良反应。 |
| 关键词: 百令胶囊 狼疮性肾炎 感染 白介素-2 补体 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Effect of Bailing Capsules on Interleukin-2, Complement and Infection Rate in Patients with Lupus Nephritis |
|
ZHU Peijun, KE Shasha, XU Fang
|
|
Department of Nephrology and Rheumatology, the Taizhou Municipal Hospital, Taizhou 318000, China
|
| Abstract: |
| OBJECTIVE To explore the effect of Bailing Capsules on interleukin-2(IL-2), complement and infection rate in patients with lupus nephritis. METHODS All of 120 patients with lupus nephritis were randomly divided into the observe group(n=60)and the control group(n=60). Patients in 2 groups all accepted the conventional treatment, while the patients in the observed group were given the treatment of Bailing Capsules (1g tid). The difference of clinical curative effect, infection rate, IL-2, complement 3(C3) and adverse drug reaction were compared between the 2 groups after 12 months. RESULTS After 12 months, compared with the control group, in the observe group, the concentrations of IL-2, C3 and serum albumin were significantly higher(P<0.05), and the concentration of urine protein, urine red blood cells and SLEDAI were significantly lower. The effective rate in the observe group(88.33%) was significantly higher than that in the control group(71.67%)(P<0.05). The infection rate during the 12 months follow up in the observe group(21.67%) was significantly lower than that in the control group(45.00%)(P<0.05). There was no significant difference of adverse drug reactions in the observe group(38.33%)and in the control group(36.67%). CONCLUSION Bailing Capsules could improve clinical curative effect and reduce the infection rate by adjusting the level of IL-2 and C3, and didn’t increase in adverse drug reactions. |
| Key words: Bailing Capsules lupus nephritis infection interleukin-2 complement |
