| 引用本文: | 武燕,刘健,吴争荣.大蒜皮中肉桂酰胺N-trans-feruloyloctopamine对老年痴呆大鼠模型的治疗作用[J].中国现代应用药学,2015,32(12):1437-1439. |
| WU Yan,LIU Jian,WU Zhengrong.Effect of N-trans-feruloyloctopamine from Garlic Skin on Alzheimer’s Disease Model Rats[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(12):1437-1439. |
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| 摘要: |
| 目的 研究大蒜皮中的肉桂酰胺类化合物N-trans-feruloyloctopamine(FO)对老年痴呆模型大鼠的治疗作用。方法 采用Meynert基底核注射Aβ1-40建立老年痴呆大鼠模型，再给予FO进行灌胃后，测定大鼠脑内乙酰胆碱(Ach)、乙酰胆碱转移酶(ChAT)及乙酰胆碱酯酶(AchE)活性等指标，HE染色后观察大鼠海马区神经细胞形态变化。结果 与模型组比较，酪氨酸酶抑制剂FO组的Ach，ChAT和AchE均具有显著性差异(P<0.05，P<0.01)；病理结果显示FO对Aβ引起的大鼠海马皮层神经元变性坏死症状明显改善。结论 FO对大鼠AD模型具有较好防治作用。 |
| 关键词: N-trans-feruloyloctopa mine 大蒜皮 酪氨酸酶 老年痴呆 |
| DOI： |
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| 基金项目:甘肃省科技计划项目(1506RJYA039) |
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| Effect of N-trans-feruloyloctopamine from Garlic Skin on Alzheimer’s Disease Model Rats |
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WU Yan1, LIU Jian2, WU Zhengrong3
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1.Gansu University of Traditional Chinese Medicine, Lanzhou 730030, China;2.The First Hospital of Lanzhou University, Lanzhou 730030, China;3.School of Pharmaceutics, Lanzhou University, Lanzhou 730030, China
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| Abstract: |
| OBJECTIVE To investigate the effects of N-trans-feruloyloctopamine from garlic skin on Alzheimer’s disease model rats. METHODS Adopted Aβ1-40 injected into meynert nuclei basales of rats to establish Alzheimer’s disease model, then the compound was given by i.g. to the Alzheimer’s disease model rats, the activities of acetylcholine, acetylcholine transferase and acetylcholinesterase of all samples were detected, the brain tissues were stained by HE staining, the ultrastructure images of the coronary slides in rat hippocampus were examined by electron microscope observation. RESULTS Compared with the model group, the related indexs had differences significantly in FO group(P<0.05, P<0.01). Pathology showed FO could protect neuron apoptosis caused by toxicity of Aβ. CONCLUSION FO has the good function to prevent and treat Alzheimer's disease on model rats. |
| Key words: N-trans-feruloyloctopamine garlic skin tyrosinase Alzheimer’s disease |
