| 引用本文: | 伍平华,杜全海,陆涛.盐酸达泊西汀的合成[J].中国现代应用药学,2016,33(2):181-183. |
| WU Pinghua,DU Quanhai,LU Tao.Improved Synthesis of Dapoxetine Hydrochloride[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(2):181-183. |
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| 摘要: |
| 目的 优化盐酸达泊西汀的合成工艺。方法 以3-氯代苯丙酮为原料经还原、醚化、二甲氨基取代、拆分、成盐反应制得目标产物。结果与结论 改进后的工艺简化了操作、降低了成本、较大程度上提高了收率，利于工业化生产。 |
| 关键词: 达泊西汀 工艺优化 选择性5-羟色胺再摄取抑制剂 |
| DOI： |
| 分类号:TQ460.1 |
| 基金项目: |
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| Improved Synthesis of Dapoxetine Hydrochloride |
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WU Pinghua1,2, DU Quanhai2, LU Tao1
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1.College of Sciences, China Pharmaceutical University, Nanjing 210009, China;2.Nanjing Kang Fushun Pharmaceutical Company Limited, Nanjing 210009, China
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| Abstract: |
| OBJECTIVE To improve the method for the synthesis of dapoxetine hydrochloride. METHODS Starting with 3-chloro-1-phenyl-1-propanone, dapoxetine hydrochloride was synthesized via a 5-step chain reaction including reduction, etherification, amination by dimethylamine, separation, and acidification by HCl·EA. RESULTS & CONCLUSION The improved process has the advantages of convenient operation, low cost, high yield, and is suitable for industry. |
| Key words: dapoxetine synthesis SSRI |
