| 引用本文: | 王恒和,程刚,刘兴磊.六五一丸(651丸)治疗冠心病心绞痛的临床观察[J].中国现代应用药学,2015,32(12):1505-1510. |
| WANG Henghe,CHENG Gang,LIU Xinglei.Clinical Observation of Liu Wu Yi Pills (651 pills) in the treatment on Angina Pectoris of Coronary Heart Disease[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(12):1505-1510. |
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| 摘要: |
| 目的 考察六五一丸(651丸)治疗冠心病心绞痛(coronary heart disease，CHD，气阴虚血瘀证)患者的疗效及其对运动耐力和生存质量的影响。方法 选择符合纳入标准的CHD患者58例，随机分为治疗组和对照组，治疗组采用CHD基础用药方案(抗血小板制剂、硝酸酯类药、β受体阻滞剂、他汀类调脂药和血管紧张素转换酶抑制剂等)加六五一丸(651丸)，对照组仅采用CHD基础用药方案治疗，均以4周为1个疗程，治疗结束后1个月随访。分析比较治疗前后2组患者的心绞痛等临床症状、心电图、心绞痛发作次数及6 min步行试验(6minute walking test，6MWT)距离和西雅图心绞痛量表(SAQ)评分等指标的变化；治疗后1月随访2组间6MWT和生存质量评分的变化。结果 治疗组心绞痛总有效率明显优于对照组(P<0.05)。治疗组与对照组心电图总有效率差异无统计学意义。治疗组硝酸甘油停减率明显高于对照组(P<0.05)。6MWT总距离2组较治疗前均显著增加(P<0.01)，但治疗组较对照组增加更明显(P<0.05)，1个月后随访这种差异更显著(P<0.01)。治疗组在“主要症状”、“伴随情况”、“认识程度”方面评分明显高于对照组(P<0.05)，而其余4个生存质量(SAQ)评分维度2组间差异无统计学意义，但1个月后随访，治疗组各维度改善均较对照组明显(P<0.05)。结论 六五一丸(651丸)可显著改善CHD患者心绞痛症状、减少硝酸甘油用量，较常规治疗方案可明显提高CHD患者运动耐力和生存质量，是冠心病心绞痛(气阴虚血瘀证)治疗安全、有效的中药制剂之一。 |
| 关键词: 六五一丸(651丸) 气阴虚血瘀证 冠心病 运动耐力 生存质量 |
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| Clinical Observation of Liu Wu Yi Pills (651 pills) in the treatment on Angina Pectoris of Coronary Heart Disease |
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WANG Henghe1, CHENG Gang2, LIU Xinglei2
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1.Department of Cardiology, First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| OBJECTIVE To investigate the Liu Wu Yi Pills (651 pills) in treatment of angina pectoris of coronary heart disease (CHD) (qi and yin deficiency and blood stasis syndrome) curative effect and influence on exercise tolerance and quality of life. METHODS Fifty-eight patients met the inclusion criteria of patients with CHD, were randomly divided into treatment group (n=30) and control group(n=28), treatment group adopted CHD based regimen(antiplatelet agents, nitrates drugs, beta blockers, statins and angiotensin converting enzyme inhibitor ACEI) plus Liu Wu Yi Pills (651 pills) in control group, onlyusing the CHD treatment, with 4 weeks for 1 courses of treatment, after the end of treatment were followed up for 1 months. Analysis and comparison of the 2 groups before and after treatment in patients with clinical symptoms such as angina, ECG, angina pectoris and 6 minute walk test and the score of the quality of life index changes; changes after treatment between the 2 groups were followed up 1 month of 6 minute walk test(6MWT) and the score of the quality of life. RESULTS the treatment of angina pectoris group total effective rate was significantly better than that in control group (P<0.05). there was no significant difference between the 2 groups of the total effective rate of ECG. nitroglycerin stopped reduction rate of treatment group was significantly higher than that of the control group (P<0.05). compared with before treatment, 6MWT distance of 2 groups were all significantly increased(P<0.01), and the treatment group increased more significantly(P<0.05), after 1 months of follow-up, the difference was more significant (P<0.01). (6) the treatment group in the "the main clinical syndrome", "associated diseases", with “disease awareness” score was significantly higher than the control group (P<0.05), while the difference between the 2 groups in while the other four dimensions no significant difference (P>0.05), but after 1 months of follow-up, the long-term improvement in the treatment group each dimension were lower than those in the control group significantly (P<0.05). CONCLUSION Liu Wu Yi Pills (651 pills) can improve the CHD patients with symptoms of angina, reduce the amount of nitroglycerin, compared with conventionaltherapy, can significantly improve the CHD patients exercise tolerance and quality of life, is one of the effective and safety treatment of traditional Chinese medicine preparation for the angina pectoris of coronary heart disease (qiyin deficiency and blood stasis syndrome). |
| Key words: Liu Wu Yi Pills qiyin deficiency and blood stasis syndrome coronary heart disease exercise tolerance quality of life |
