| 引用本文: | 康小龙,何承辉,田红林,何强.刺山柑总生物碱乳膏外用对系统性硬皮病小鼠组织纤维化的改善作用[J].中国现代应用药学,2016,33(1):32-35. |
| KANG Xiaolong,HE Chenghui,TIAN Honglin,HE Qiang.Effect of Capparis Spinosa Total Alkaloid Cream on the Tissue Fibrosis in Systemic Sclerosis Mice[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(1):32-35. |
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| 摘要: |
| 目的 研究刺山柑总生物碱乳膏外用对系统性硬皮病(systemic sclerosis，SSc)小鼠组织纤维化的改善作用。方法 BALB/c小鼠背部注射盐酸博莱霉素建立SSc模型，外用刺山柑总生物碱乳膏进行干预后，比较给药前后小鼠真皮厚度的变化，ELISA法检测小鼠皮肤及肺组织羟脯氨酸(Hyp)和Ⅰ型胶原(Col-Ⅰ)表达水平。结果 刺山柑总生物碱乳膏中、高剂量可明显降低SSc小鼠真皮厚度，同时可降低小鼠皮肤及肺组织Hyp含量(P<0.05或0.01)，高剂量还可降低肺组织Col-Ⅰ含量(P<0.01)。结论 刺山柑总生物碱乳膏对SSc组织纤维化有一定改善作用。 |
| 关键词: 刺山柑总生物碱乳膏 系统性硬皮病 组织纤维化 Ⅰ型胶原 |
| DOI： |
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| 基金项目:国家自然科学基金资助项目(81260235) |
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| Effect of Capparis Spinosa Total Alkaloid Cream on the Tissue Fibrosis in Systemic Sclerosis Mice |
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KANG Xiaolong1, HE Chenghui2, TIAN Honglin1, HE Qiang1
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1.Hospital of Chinese Medicine Affiliated to Xinjiang Medical University, Urumqi 830000, China;2.Xinjiang Medicine Research Institute, Urumqi 830004, China
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| Abstract: |
| OBJECTIVE To investigate the effect of Capparis Spinosa Total Alkaloid cream on the tissue fibrosis in systemic sclerosis(SSc) mice. METHODS SSc mice model was established by repeated local injections of bleomycin in BALB/c mice back. After therapy by Capparis Spinosa Total Alkaloid cream, the dermis thickness was examined, and the hydroxyproli(Hyp) and collagen-Ⅰ(Col-Ⅰ) content in the skin and lung tissue were detected by ELISA. RESULTS Compared with the model group, the dermis thickness and the levels of Hyp in the skin tissues were markedly decreased by moderate and high dose of Capparis Spinosa Total Alkaloid cream(P<0.05 or 0.01). The level of Col-Ⅰ in the lung tissue was markedly decreased by high dose Capparis Spinosa Total Alkaloid cream(P<0.01). CONCLUSION Capparis Spinosa Total Alkaloid cream is effective in treating fibrosis of SSc. |
| Key words: Capparis Spinosa Total Alkaloid cream systemic sclerosis fibrosis collagen-Ⅰ |
