| 引用本文: | 徐雄良,岳韵,刘小均,杨刚,刘浪,柯潇,郑强.一清胶囊抗甲型H1N1流感病毒作用[J].中国现代应用药学,2015,32(9):1056-1058. |
| XU Xiongliang,YUE Yun,LIU Xiaojun,YANG Gang,LIU Lang,,KE Xiao,,ZHENG Qiang.Anti-virus Effect of Yiqing Capsule on Influenza A Subtype H1N1[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(9):1056-1058. |
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| 摘要: |
| 目的 研究一清胶囊抗甲型H1N1流感病毒作用。方法 采用小鼠气管内注入甲型流感病毒鼠肺适应株A/PR/8/34(H1N1)病毒液建立病毒感染小鼠模型，以肺指数、肺指数抑制率、小鼠累积死亡率为指标，评价一清胶囊体内抗甲型H1N1流感病毒作用。结果 7.3 g·kg-1一清胶囊(原生药)可降低病毒感染小鼠的肺脏指数(P<0.05)和小鼠感染病毒后7~9 d内的死亡率(P<0.01)。结论 一清胶囊具有明显的抗甲型H1N1流感病毒作用。 |
| 关键词: 一清胶囊 抗病毒 甲型H1N1流感病毒 |
| DOI： |
| 分类号:R285.5 |
| 基金项目: |
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| Anti-virus Effect of Yiqing Capsule on Influenza A Subtype H1N1 |
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XU Xiongliang, YUE Yun, LIU Xiaojun, YANG Gang, LIU Lang,, KE Xiao,, ZHENG Qiang
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National-recognized Enterprise Technology Center, Chengdu Kanghong Pharmaceuticals Group Co., Ltd., Chengdu 610036, China
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| Abstract: |
| OBJECTIVE To evaluate the antivirus effect of Yiqing capsule. METHODS Antivirus test in vivo of Yiqing capsule was carried out by intratracheal injection of influenza A strains A/PR/8/34 (H1N1) strain in mice. The lung index, inhibition rate of lung index and death rate of mice were measured to observe the effect of anti-influenza A virus subtype H1N1 in vivo. RESULTS The 7.3 g·kg-1 Yiqing capsule(crude) could significantly decrease the lung index of viral infected mice (P<0.05) and the mortality of 7-9?d in viral infected mice(P<0.01). CONCLUSION Yiqing capsule has good effect of anti-influenza A virus subtype H1N1 in vivo. |
| Key words: Yiqing capsule anti-virus influenza A virus subtype H1N1 |
