| 引用本文: | 方军伟,张智勤,潘锦辉,多娜,陈华忠.土三七致肝小静脉闭塞病的血小板及凝血功能临床表现分析[J].中国现代应用药学,2015,32(7):874-875. |
| FANG Junwei,ZHANG Zhiqin,PAN Jinhui,DUO Na,CHEN Huazhong.Analysis of the Clinical Manifestations of Platelet and Coagulation Function in Gynura Segetum Merr. Induced Hepatic Venular Occlusive Disease[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(7):874-875. |
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| 摘要: |
| 目的 分析土三七所致的肝小静脉闭塞病(hepatic venular occlusive disease，HVOD)的血小板及凝血功能的临床表现。方法 搜集35例外伤后服用土三七致HVOD的血小板及凝血功能临床资料，结合文献报道进行分析。结果 35例患者中，32例血小板小于正常值，占91.4%，检测值为(81.94±17.92)×109·L-1；凝血酶原时间延长33例，占94.2%，检测值为(18.73±3.28)s，国际标准化比值检测值为1.76±0.35，部分活化凝血酶原时间检测值为(42.35±6.57)s。结论 临床上土三七致HVOD血小板数量减少、凝血功能受抑制，应用活血化瘀、抗凝为主的方案治疗土三七致HVOD有待进一步研究。 |
| 关键词: 土三七 肝小静脉闭塞症 血小板 凝血功能 |
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| 基金项目:浙江省中医药科技计划基金资助项目(2010ZB160)；浙江省仙居县社会科学重点项目(2009C02) |
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| Analysis of the Clinical Manifestations of Platelet and Coagulation Function in Gynura Segetum Merr. Induced Hepatic Venular Occlusive Disease |
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FANG Junwei1, ZHANG Zhiqin1, PAN Jinhui1, DUO Na1, CHEN Huazhong2
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1.TCM Hospital Xianju, Xianju 317300, China;2.Taizhou Hospital of Zhejiang Province, Taizhou 317000, China
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| Abstract: |
| OBJECTIVE To analysis of clinical manifestations of platelet and coagulation function in Gynura segetum Merr. induced hepatic venular occlusive disease(HVOD). METHODS The 35 cases with Gynura segetum Merr. induced HVOD were selected. The clinical data of the patients were analysed referring to reported literature. RESULTS In 35 cases, the platelet count of 32 cases were lower than normal, accounting for 91.4%, the value was (81.94±17.92)×109·L-1. The prothrombin time of 33 cases was prolonged, accounting for 94.2%. The value was (18.73±3.28)s. The international normalized ratio was 1.76±0.35. The activated partial thromboplastin time was (42.35±6.57)s. CONCLUSION The platelets content of Gynura segetum Merr. induced HVOD clinically and the coagulation function is inhibited. The therapy of romoting blood circulation for removing blood stasis and the anticoagulation of Gynura segetum Merr. induced HVOD need to be explored further. |
| Key words: Gynura segetum Merr. hepatic venular occlusive disease platelet coagulation function |
