| 引用本文: | 陈瑜,金立,俞辉,洪利娅.HPLC测定三层共挤输液用袋中抗氧剂PEPQ的含量[J].中国现代应用药学,2015,32(8):963-965. |
| CHEN Yu,JIN Li,YU Hui,HONG Liya.Content Determination of Antioxidants PEPQ in Infusion of 3-layer Co-extrusion Bags by HPLC[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(8):963-965. |
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| 摘要: |
| 目的 建立三层共挤输液用袋中抗氧剂四(2,4-二叔丁基酚)-4,4-联苯基二亚磷酸酯(PEPQ)的含量测定法。方法 采用Dikma Diamonsil C18色谱柱(250 mm×4.6 mm，5 μm)，流动相为乙腈-四氢呋喃(80∶20)，柱温30 ℃，检测波长270 nm。结果 抗氧剂PEPQ在0~200.0 μg·mL-1内呈良好的线性关系(r=0.999)，抗氧剂PEPQ回收率为92.3%(RSD=1.97%)。结论 该方法准确、灵敏、简便，适用于测定三层共挤输液用袋中抗氧剂PEPQ的含量。 |
| 关键词: 高效液相色谱法 三层共挤输液用袋 抗氧剂四(2,4-二叔丁基酚)-4,4-联苯基二亚磷酸酯 |
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| 基金项目:浙江省省级重点实验室(2014E10006)；浙江省科技厅公益性技术应用研究计划项目(2015C37028) |
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| Content Determination of Antioxidants PEPQ in Infusion of 3-layer Co-extrusion Bags by HPLC |
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CHEN Yu, JIN Li, YU Hui, HONG Liya
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Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China
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| Abstract: |
| OBJECTIVE To develop a method for content determination of PEPQ infusion of 3-layer co-extrusion bags by HPLC. METHODS The analysis was performed on Dikma Diamonsil C18(250 mm×4.6 mm, 5 μm) column, using acetonitrile-tetrahydrofuran(80∶20), Column temperature 30 ℃ and detection wavelength 270 nm. RESULTS The method has a linear range between 0-200.0 μg·mL-1(r=0.999), The average recovery of antioxidants PEPQ was 92.3%(RSD=1.97%). CONCLUSION This method is accurate, sensitive, simple, it can be used for content determination of antioxidants PEPQ in infusion of 3-layer co-extrusion bags. |
| Key words: HPLC infusion of 3-layer co-extrusion bags antioxidants PEPQ |
