四氯化碳诱导肝损伤的分子机制及中药干预的研究进展

尹连红; 于浩; 彭金咏<sup>*</sup>

引用本文:	尹连红,于浩,彭金咏.四氯化碳诱导肝损伤的分子机制及中药干预的研究进展[J].中国现代应用药学,2015,32(9):1147-1155.
	YIN Lianhong,YU Hao,PENG Jinyong.Molecular Mechanism and Intervention of Chinese Medicine of Carbon Tetrachloride Induced Liver Injury[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(9):1147-1155.

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四氯化碳诱导肝损伤的分子机制及中药干预的研究进展
尹连红, 于浩, 彭金咏
大连医科大学药学院，辽宁大连 116044

摘要:

目前，肝脏疾病已经成为威胁人类健康的常见疾病之一。四氯化碳(CC1₄)是一种常见的肝毒性化合物，可诱导急性肝损伤、肝纤维化、肝硬化和肝癌等肝脏疾病的发生。CC1₄诱导的肝损伤实验动物模型被广泛应用于保肝药物的筛选，且药理学研究发现许多中药对该类疾病具有良好的治疗作用。本文综述了近年来CC1₄诱导肝损伤的分子机制的研究进展和中药干预情况，为进一步阐明肝脏疾病发生、发展的内在机制及其预治提供依据。

关键词: 四氯化碳肝损伤分子机制中药干预

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基金项目:国家自然科学基金(81274195)；辽宁省教育厅高等学校创新团队(LT2013019)

Molecular Mechanism and Intervention of Chinese Medicine of Carbon Tetrachloride Induced Liver Injury

YIN Lianhong, YU Hao, PENG Jinyong

College of Pharmacy, Dalian Medical University, Dalian 116044, China

Abstract:

Liver disease has become one of the common diseases threatening human health. Carbon tetrachloride (CCl₄) is a common compound for liver toxicity, which can induce liver diseases, such as acute liver injury, liver fibrosis, cirrhosis and liver cancer etc. Currently, the experimental animals with liver injury induced by CCl₄ have been widely used for screening liver protection drugs. Pharmacological researches find that many Chinese medicines have therapeutic effect on the diseases. The research progress of molecular mechanism and intervention of Chinese medicines of liver injury induced by CCl₄ are reviewed in this paper to provide a basis for clarifying the mechanism of liver disease and its prevention and treatment.

Key words: carbon tetrachloride liver injury molecular mechanism intervention of Chinese medicine