| 引用本文: | 胡楠,卞筱泓,许激扬.抗肿瘤活性多肽的研究现状[J].中国现代应用药学,2015,32(9):1155-1160. |
| HU Nan,BIAN Xiaohong,XU Jiyang.Advancement of Polypeptides with Anti-tumor Activity[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(9):1155-1160. |
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| 摘要: |
| 由于发病率和死亡率的逐年攀升，恶性肿瘤目前成为威胁人类健康的重大疾病，对于恶性肿瘤的高效治疗已成为医学领域的研究热点。随着小分子化学药物开发难度的增大，具有高效低毒等诸多优点的活性多肽开始受到重视，相关药物市场也不断扩大。本文通过对抗肿瘤活性多肽的特点与来源、制备技术、结构修饰、作用机制及研发现状等方面进行综述，为后续的研究工作提供参考。 |
| 关键词: 活性多肽 抗肿瘤 机制 临床试验 |
| DOI： |
| 分类号: |
| 基金项目:江苏省社会发展基金项目(BE2012742) |
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| Advancement of Polypeptides with Anti-tumor Activity |
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HU Nan, BIAN Xiaohong, XU Jiyang
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School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China
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| Abstract: |
| With the rising of the morbidity and mortality rates, malignant tumor has become a major threat to human health. Due to the small chemical drugs made more difficulties in development, active peptides with many advantages, such as high efficiency and low toxicity, have received more attention. The characteristics, sources, preparation methods, structure modification and mechanism of peptide were summarized in this paper. The reference will be provided and helpful for future research work, especially to the current research of the peptides in clinical trials. |
| Key words: active peptides anti-tumor mechanism clinic trials |
