| 引用本文: | 刘顶鼎,郭建生.降钙素基因相关肽与偏头痛三叉神经血管系统机制的关系[J].中国现代应用药学,2015,32(3):381-385. |
| LIU Dingding,GUO Jiansheng.Correlation Between Calcitonin Gene-related Peptide and Trigeminal Vascular System in Migraine[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(3):381-385. |
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| 摘要: |
| 降钙素基因相关肽(calcitonin gene-related peptide，CGRP)是目前已知的体内作用最强的内源性舒血管活性肽。近年来CGRP已成为国内外偏头痛治疗领域的研究热点，大量文献显示其在偏头痛三叉神经血管系统(trigeminal vascular system，TGVS)中发挥重要作用，甚至有的研究者认为抑制CGRP的释放和CGRP受体的活性是偏头痛治疗的关键切入点。由此，本文通过综述国内外关于CGRP及偏头痛三叉神经血管系统机制文献，以期能阐明偏头痛发作中CGRP的作用，为基于CGRP的已有治疗药物和新的偏头痛治疗药物提供理论支持。 |
| 关键词: 偏头痛 CGRP 三叉神经血管系统 |
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| 基金项目:湖南省高校创新平台开发基金项目(11K048)；湖南省研究生科研创新项目(CX2013B329) |
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| Correlation Between Calcitonin Gene-related Peptide and Trigeminal Vascular System in Migraine |
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LIU Dingding, GUO Jiansheng
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Hunan University of Chinese Medicine, Changsha 410208, China
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| Abstract: |
| Calcitonin gene related peptide(Calcitonin gene-related peptide, CGRP) is currently known as the strongest endogenous active peptide of diastolic blood vessels in the body. In recent years, CGRP has become a hot research topic in the field of treating migraine at home and abroad. A large number of literature shows that the trigeminal vascular system(TGVS) plays an important role in migraine. Even some researchers pointed that inhibiting the release of CGRP and the activity of CGRP receptor is the key point of migraine treatment. In order to clarify the role of CGRP in migraine attac and to provide theoretical support for existing drugs and developing new migraine drug treatment, the paper reviews the domestic and foreign literature about CGRP and mechanism of migraine trigeminal vascular system. |
| Key words: migraine calcitonin gene-related peptide trigeminal vascular system |
