阿司匹林与异钩藤碱合用的抗血小板聚集作用

张玮; 周元分; 郝星; 石京山; 谢笑龙<sup>*</sup>

引用本文:	张玮,周元分,郝星,石京山,谢笑龙.阿司匹林与异钩藤碱合用的抗血小板聚集作用[J].中国现代应用药学,2015,32(3):295-297.
	ZHANG Wei,ZHOU Yuanfen,HAO Xing,SHI Jingshan,XIE Xiaolong.Effects of Combination of Aspirin and Isorhynchophylline on Antiplatelet Aggregation[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(3):295-297.

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阿司匹林与异钩藤碱合用的抗血小板聚集作用
张玮¹, 周元分¹, 郝星², 石京山¹, 谢笑龙¹
1.遵义医学院药理学教研室暨贵州省基础药理重点实验室，贵州遵义 563000;2.遵义医学院附属医院心血管内科，贵州遵义 563000

摘要:

目的观察阿司匹林(ASP)与异钩藤碱(Iso)合用对家兔体外血小板聚集的影响。方法通过体外血小板聚集实验，采用比浊法测定ASP与Iso合用对胶原(Col)、凝血酶(Thr)及二磷酸腺苷(ADP)诱发的家兔血小板聚集率的影响。结果 ASP与Iso合用可抑制由Col(50 mg?L^-1)、Thr(3 U?mL^-1)及ADP(15 μmol?L^-1)诱导的血小板聚集。结论 ASP与Iso合用能协同抑制家兔体外血小板聚集。

关键词: 阿司匹林异钩藤碱血小板聚集

DOI：

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基金项目:

Effects of Combination of Aspirin and Isorhynchophylline on Antiplatelet Aggregation

ZHANG Wei¹, ZHOU Yuanfen¹, HAO Xing², SHI Jingshan¹, XIE Xiaolong¹

1.Department of Pharmacology of Zunyi Medical College and Key Laboratory of Basic Pharmacology of Guizhou Province, Zunyi 563000, China;2.Department Cardiovascular of Affiliated Hospital of Zunyi Medical College, Zunyi 563000, China

Abstract:

OBJECTIVE To investigate the effects of the combination of aspirin(ASP) and isorhynchophylline(Iso) on rabbit platelet aggregation in vitro. METHODS The rabbit platelet aggregation induced by collagen(Col), thrombin(Thr), and adenosine diphosphate(ADP) in vitro was determined by Born method, respectively. RESULTS Combination of ASP and Iso concentration-dependently inhibited platelet aggregation induced by Col(50 mg?L^-1), Thr(3 U?mL^-1) and ADP(15 μmol?L^-1). CONCLUSION Combination of ASP and Iso has the effect of synergistic inhibition on platelet aggregation.

Key words: aspirin isorhynchophylline platelet aggregation