| 引用本文: | 郑仁礼,张晓春,陈敏.复方护肺颗粒抑菌、抗炎作用研究[J].中国现代应用药学,2015,32(2):144-147. |
| ZHENG Renli,ZHANG Xiaochun,CHEN Min.Study on the Bacteriostasis and Anti-inflammation Effects of the Compound Lung Protecting Granules[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(2):144-147. |
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| 摘要: |
| 目的 研究复方护肺颗粒的抑菌、抗炎作用。方法 抑菌作用采用体外抑菌试验，抗炎作用采用二甲苯致小鼠耳廓肿胀、角叉菜胶致大鼠足跖肿胀、2%SO2雾化使小鼠出现慢性支气管炎症状，观察复方护肺颗粒的抑菌和抗炎作用。结果 复方护肺颗粒对肺炎杆菌、绿脓杆菌的最低抑菌浓度(MIC)为0.15 g·mL-1、对金黄色葡萄球菌的MIC为0.04 g·mL-1。与对照组相比，复方护肺颗粒高剂量组(32.24 g·kg-1)、中剂量组(16.12 g·kg-1)对二甲苯所致小鼠耳廓肿胀和角叉菜胶致大鼠足跖肿胀具有抑制作用，差异有统计学差异(P<0.01或P<0.05)，其抗炎作用具有剂量依赖性；各用药组对慢性支气管炎小鼠的气管、支气管黏膜上皮及壁管呈不同程度的慢性炎性病变、细支气管上皮轻度变性或无明显病变、肺组织无明显病变。结论 复方护肺颗粒具有良好的抑菌、抗炎作用。 |
| 关键词: 复方护肺颗粒 抑菌作用 抗炎作用 |
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| Study on the Bacteriostasis and Anti-inflammation Effects of the Compound Lung Protecting Granules |
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ZHENG Renli, ZHANG Xiaochun, CHEN Min
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Affiliated Suizhou Hospital of Hubei University of Medicine, Suizhou Central Hospital, Suizhou 441300, China
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| Abstract: |
| OBJECTIVE To investiate the bacteriostasis and anti-inflammation function of the Compound Lung Protecting granules. METHODS Use the minimum inhibitory concentration(MIC) values in vitro to observe the bacteriostasis effect. The anti-inflammation function of the Compound Lung Protecting granules was analyzed by its inhibition to the swelling of mouse pinna induced by dimethylbenzene, carrageenan induced rats’ paw edema, and by its inhibition to the chronic bronchitis of mouse pinna induced by 2% sulfur dioxide. RESULTS The MIC of the Klebsiella pneumoniae and Pseudomonas aeruginosa was 0.15 g·mL-1. The MIC of the Staphylococcus aureus was 0.04 g·mL-1. There were statistically significant difference between the larg dosage(32.24 g·kg-1), middle dosage(16.12 g·kg-1) with the physiological saline. The dose of 32.24 g·kg-1 and 16.12 g·kg-1 against carrageenan induced rats’ paw edema, and disinfection of drinking water group were significant different(P<0.01 or P<0.05), and its anti-inflammatory effects were dose-dependent. Every treatment groups had different degree chronic inflammation of mouse bronchial epithelium. The lung tissue of mouse had no reveal cytopathic. CONCLUSION Compound Lung Protecting granules have bacteriostasis and anti-inflammation effects. |
| Key words: Compound Lung Protecting granules bacteriostasis effect anti-inflammation effect |
