| 引用本文: | 彭华毅,阙慧卿,钱丽萍,林绥.雷公藤内酯醇贴剂抗炎、镇痛作用研究[J].中国现代应用药学,2014,31(9):1037-1041. |
| PENG Huayi,QUE Huiqing,QIAN Liping,LIN Sui.Anti-inflammatory and Analgesic Effect of Triptolide Patches[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(9):1037-1041. |
|
| 摘要: |
| 目的 研究雷公藤内酯醇贴剂的抗炎、镇痛作用。方法 通过小鼠耳廓肿胀、毛细血管通透性、肉芽肿以及大鼠角叉菜胶致炎实验，观察贴剂的抗炎效果；通过热板法、扭体法和电刺激法，观察贴剂的镇痛效果。结果 贴剂在雷公藤内酯醇含量为3.72，7.44，14.88 mg·m-2内能有效抑制由二甲苯诱发的小鼠耳廓肿胀、腹部皮肤毛细血管通透性增高现象，抑制纸片引起小鼠肉芽组织增生以及角叉菜胶致大鼠足趾肿胀；并对醋酸所致小鼠腹痛扭体有抑制作用，提高鼠尾电刺激痛阈值。结论 雷公藤内酯醇贴剂对急、慢性炎症有良好抑制作用，对化学性刺激有一定镇痛效果。 |
| 关键词: 雷公藤内酯醇 抗炎 镇痛 |
| DOI： |
| 分类号: |
| 基金项目:国家卫生与计划生育委员会科研基金(WKJ-FJ-15)；福建省科技重大专项(2009YZ0001-1-3)；福建省省属公益类科研院所基本科研专项(2011R1034-3；2013R0034-1)；福建省自然科学基金项目(2013J01367)；福建省卫生厅青年科研基金项目(2012-1-14)；福建省卫生厅中医药科研项目(wzze201306) |
|
| Anti-inflammatory and Analgesic Effect of Triptolide Patches |
|
PENG Huayi1,2, QUE Huiqing1, QIAN Liping1, LIN Sui1
|
|
1.Fujian Medical Science Research Institute, Fuzhou 350001, China;2.Inspection and Quarantine Technique Centre of Fujian Entry-exit Inspection and Quarantine Bureau, Fuzhou 350003, China
|
| Abstract: |
| OBJECTIVE To investigate the anti-inflammatory and analgesic effects of triptolide patches. METHODS The mice ears swelling test, abdominal capillary permeability test, filter-paper-induced granuloma and carrageenin-induced pedal edema in the rats were used to observe the anti-inflammatory effect. While the hot plate test, writhing test and electrical stimulation test were adopted to study the analgesic effect of triptolide patches. RESULTS In the four anti-inflammatory animal models, the effects of triptolide patches (3.72, 7.44 and 14.88 mg·m-2) were observed. It also decreased twisting number induced by acetic acid, and improved threshold of pain to electric stimulation. CONCLUSION Triptolide patches can inhibit the inflammation and pain reaction. |
| Key words: triptolide anti-inflammatory effect analgesic effects |
