| 引用本文: | 陈子晞,陈方慧.临床常见病原菌对替加环素耐药机制研究进展[J].中国现代应用药学,2014,31(11):1423-1426. |
| CHEN Zixi,CHEN Fanghui.Advances in Resistant Mechanisms of Clinical Isolated Bacteria to Tigecycline[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(11):1423-1426. |
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| 摘要: |
| 目的 探讨临床常见耐药菌对替加环素产生耐药的机制，对相关研究进展进行综述。方法 综述了近年来国内外相关报道，根据细菌产生耐药的机制进行分类阐述，并对替加环素耐药菌的流行情况进行分析。结果 细菌对替加环素产生耐药的机制主要与主动外排系统有关，另外还包括药物作用靶位的改变、耐药酶的产生2个方面。在主动外排机制中，RND家族外排泵起着关键作用。替加环素耐药菌在许多国家已经成为临床抗感染难题。结论 替加环素耐药机制还需要进一步研究，从而指导临床合理使用替加环素。 |
| 关键词: 细菌 替加环素 耐药 外排泵 |
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| Advances in Resistant Mechanisms of Clinical Isolated Bacteria to Tigecycline |
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CHEN Zixi, CHEN Fanghui
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The First People’s Hospital of Hangzhou, Hangzhou 310006, China
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| Abstract: |
| OBJECTIVE To review the research progress on the resistant mechanisms of tigecycline-resistant bacterias in clinic. METHODS Base on the correlative reports in recent years, the resistant mechanisms of tigecycline-resistant bacterias were illustrated respectively. Also, the epidemiology of tigecycline-resistant bacterias were analyzed subsequently. RESULTS The resistant mechanisms of tigecycline-resistant bacterias mainly involved the efflux pump system and alteration of the drug targets, as well as the occurrence of resistant enzymes. The RND efflux pump plays a key role in the efflux pump system. Tigecycline-resistant bacterias has become a tough problem in clinical anti-infection therapy. CONCLUSION The definite mechanism of tigecycline resistant remains elusive. Further study are needed so as to guide rational use of tigecycline in clinic. |
| Key words: bacteria tigecycline drug resistance efflux pump |
