| 引用本文: | 徐先祥,秦思,李琼.桦木酸抗炎作用与机制[J].中国现代应用药学,2014,31(10):1284-1287. |
| XU Xianxiang,QIN Si,LI Qiong.Anti-inflammatory Effects and Mechanisms of Betulinic Acid[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(10):1284-1287. |
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| 摘要: |
| 目的 对桦木酸的抗炎作用与机制进行综述。方法 检索归纳有关桦木酸抗炎作用的文献，对其作用途径及机制进行了分析。结果 桦木酸对实验性炎症模型及其他模型有显著的抗炎作用，桦木酸抗炎作用机制涉及糖皮质激素受体、一氧化氮、氧化应激、免疫调节、细胞因子和黏附分子、炎性信号通路等。此外，桦木酸与其他天然产物还有协同的抗炎作用。结论 桦木酸通过多途径发挥抗炎作用，抗炎活性研究对于探讨桦木酸治疗疾病的作用机制有着重要意义。 |
| 关键词: 桦木酸 抗炎 作用机制 信号通路 协同作用 |
| DOI： |
| 分类号:R285 |
| 基金项目:福建省科技计划重点项目(2012Y0049)；泉州市科技计划项目(2011Z8)；华侨大学中央高校基本科研业务费“福建省杰出青年基金培育计划”专项(JB-SJ1012) |
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| Anti-inflammatory Effects and Mechanisms of Betulinic Acid |
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XU Xianxiang, QIN Si, LI Qiong
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School of Biomedical Science, Huaqiao University, Quanzhou 362021, China
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| Abstract: |
| OBJECTIVE To review anti-inflammatory effects of betulinic acid and the mechanisms. METHODS Literature about anti-inflammatory effects of betulinic acid was summarized and the pathways and mechanisms were analyzed. RESULTS Betulinic acid had significant anti-inflammatory effects on experimental inflammatory models and other models. The anti-inflammatory mechanisms involved glucocorticoid receptor, nitric oxide, oxidative stress, immune regulation, cytokines, adhesion molecules and inflammatory signaling pathways. In addition, betulinic acid could perform synergistic anti- inflammatory action with other natural products. CONCLUSION Betulinic acid exerts anti-inflammatory effects through multiple pathways. Studies on the anti-inflammatory activities of betulinic acid have important significance for the mechanism of its therapeutic effects. |
| Key words: betulinic acid anti-inflammation mechanism signaling pathways synergistic action |
