18α-甘草酸固体脂质纳米粒抗大鼠急性肝损伤作用研究

王维; 潘旭旺<sup>*</sup>; 邵益丹; 席建军; 庄让笑

引用本文:	王维,潘旭旺,邵益丹,席建军,庄让笑.18α-甘草酸固体脂质纳米粒抗大鼠急性肝损伤作用研究[J].中国现代应用药学,2014,31(7):798-802.
	WANG Wei,PAN Xuwang,SHAO Yidan,XI Jianjun,ZHUANG Rangxiao.Protective Effect of 18α-Glycyrrhizic Acid Solid Lipid Nanoparticles on Acute Liver Injury in Rats[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(7):798-802.

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18α-甘草酸固体脂质纳米粒抗大鼠急性肝损伤作用研究
王维¹, 潘旭旺², 邵益丹², 席建军², 庄让笑²
1.浙江省人民医院，杭州 310014;2.杭州市西溪医院，杭州 310023

摘要:

目的研究18α-甘草酸固体脂质纳米粒(18α-glycyrrhizic acid solid lipid nanoparticles，18α-GL-SLN)的抗大鼠急性肝损伤作用。方法用CCl₄致大鼠急性肝损伤，以生化指标和病理变化评价18α-GL-SLN的抗肝损伤作用。结果与模型组比较，18α-GL-SLN各剂量组和18α-GL组ALT、AST、TBil、γ-GT、ALP水平明显降低，差异有统计学意义( P <0.05)，提示对大鼠急性肝损伤均有一定的治疗作用，尤其是18α-GL-SLN中、高剂量组，效果优于18α-GL组( P <0.05)；病理切片显示各给药组肝组织损伤明显减轻。结论 18α-GL-SLN有抗CCl4致大鼠急性肝损伤作用，并且其作用优于18α-GL。

关键词: 18α-甘草酸固体脂质纳米粒急性肝损伤四氯化碳

DOI：

分类号:

基金项目:杭州市医药卫生科技计划项目(2008A019)

Protective Effect of 18α-Glycyrrhizic Acid Solid Lipid Nanoparticles on Acute Liver Injury in Rats

WANG Wei¹, PAN Xuwang², SHAO Yidan², XI Jianjun², ZHUANG Rangxiao²

1.Zhejiang Provincial People's Hospital, Hangzhou 310014, China;2.Hangzhou Xixi Hospital, Hangzhou 310023, China

Abstract:

OBJECTIVE To investigate the protective effect of 18α-glycyrrhizic acid solid lipid nanoparticles (18α-GL-SLN) on acute liver injury in rats. METHODS Acute liver injury in rats was caused by CCl₄, and the protective effect of 18α-GL-SLN was evaluated with biochemical indicator and pathological change. RESULTS Compared with model group, different dosages groups of 18α-GL-SLN and 18α-GL group all obviously degraded the level of ALT, AST, TBil, γ-GT and ALP, it had statistical significance( P <0.05). This showed that the three groups of 18α-GL-SLN and the group of 18α-GL all had protective effect on acute liver injury in rats, and the effect of middle and high dose groups of 18α-GL-SLN were even better than group of 18α-GL( P <0.05). The pathological changes revealed that liver injury was relieved in all treated groups. CONCLUSION 18α-GL-SLN has the protective effect on acute liver injury in rats, and it resulted a better effect than 18α-GL.

Key words: 18α-GL solid lipid nanoparticles acute liver injury carbon tetrachloride