| 引用本文: | 李煜,孔祥文,楼永军,洪利娅.癌症研究与临床治疗中的CDK抑制剂[J].中国现代应用药学,2014,31(9):1147-1154. |
| LI Yu,KONG Xiangwen,LOU Yongjun,HONG Liya.CDK Inhibitors in Cancer Research and Clinical Therapy[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(9):1147-1154. |
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| 摘要: |
| 目的 综述CDK抑制剂及其在癌症研究与治疗中的应用，帮助研究人员寻找适合于特定研究目的的小分子CDK抑制剂。方法 对17种CDK抑制剂的研究进展进行综述，同时提供了每种抑制剂的作用靶点、商业供应情况和IC50值。结果 CDK抑制剂已在癌症研究和临床应用中呈现出良好的抗癌作用。结论 随着研究的不断深入，CDK抑制剂有望成为新一代抗癌药物。 |
| 关键词: CDK 激酶 小分子抑制剂 癌症 细胞周期 |
| DOI： |
| 分类号:R284.1；R917.101 |
| 基金项目: |
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| CDK Inhibitors in Cancer Research and Clinical Therapy |
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LI Yu1, KONG Xiangwen2, LOU Yongjun1, HONG Liya1
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1.Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China;2.Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd., Hangzhou 310004, China
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| Abstract: |
| OBJECTIVE To review CDK inhibitors and their use in cancer research or therapy, and help researchers to search for small-molecule CDK inhibitors which best suited for the specific purpose of their research. METHODS Seventeen CDK inhibitors recently developed were reviewed. The targets, commercial availability and IC50 values of each inhibitor were also provided. RESULTS The potent anticancer effects of CDK inhibitors had been revealed in cancer research and clinical therapy. CONCLUSION With the further research, CDK inhibitors will be new anticancer drugs. |
| Key words: CDK kinases small-molecule inhibitors cancer cell cycle |
