| 引用本文: | 李清娟,陈卫平,樊俊红,赵倩,李晓花,杨启,刘翠艳.多花蒿化学成分研究[J].中国现代应用药学,2014,31(6):706-710. |
| LI Qingjuan,CHEN Weiping,FAN Junhong,ZHAO Qian,LI Xiaohua,YANG Qi,LIU Cuiyan.Study on the Chemical Constituents of Artemisia Myriantha Wall. Ex Bess.[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(6):706-710. |
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| 多花蒿化学成分研究 |
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李清娟, 陈卫平, 樊俊红, 赵倩, 李晓花, 杨启, 刘翠艳
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河北省制剂工程技术研究中心，石药集团中奇制药技术(石家庄)有限公司，石家庄 050035
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| 摘要: |
| 目的 研究多花蒿(Artemisia myriantha)的化学成分。方法 运用硅胶、凝胶等多种色谱技术对多花蒿的化学成分进行研究，并根据理化性质和波谱数据鉴定化合物结构。结果 分离鉴定了11个化合物，分别是arglabin(1)，13-acetoxy-3β-hydroxy-germacra-1(10)E, 4E, 7(11)-trien-12, 6α-olide(2)，半齿泽兰素(3)，8α-acetoxyarglabin(4)，artemyriantholide B(5)，artemyriantholide A(6)，4', 5, 7-三羟基-6，3'-二甲氧基黄酮(7)，紫花牡荆素(8)，5, 4'-二羟基-6, 7, 3',5'-四甲氧基黄酮(9)，arborescin(10)，arlatin(11)。结论 化合物3，7~11为首次从该植物中分离得到。 |
| 关键词: 多花蒿 化学成分 黄酮 倍半萜内酯 |
| DOI： |
| 分类号:R284.1;R917.101 |
| 基金项目:“重大新药创制”国家科技重大专项(2010ZX09401-402) |
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| Study on the Chemical Constituents of Artemisia Myriantha Wall. Ex Bess. |
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LI Qingjuan, CHEN Weiping, FAN Junhong, ZHAO Qian, LI Xiaohua, YANG Qi, LIU Cuiyan
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Hebei Pharmaceutical Technology and Engineering Research Center, Shijiazhuang Pharm. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd., Shijiazhuang 050035, China
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| Abstract: |
| OBJECTIVE To study the chemical constituents of Artemisia myriantha Wall. ex Bess.. METHODS Silica gel column, Sephadex LH-20 column chromatography were used for separation and purification of the compounds and extensive spectral analysis spectrum were employed for structural elucidation. RESULTS Eleven compounds were isolated and identified as arglabin(1), 13-acetoxy-3β-hydroxyl-germacra-1(10)E, 4E, 7(11)-trine-12, 6α-olide(2), eupatorin(3), 8α-acetoxyarg- labin(4), artemyriantholide B(5), artemyriantholide A(6), 4', 5, 7-trihydroxy-6, 3'-dimethoxy flavone(7), casticin(8), 5, 4'-dihydroxy-6, 7, 3', 5'-tetramethoxy flavone(9), arborescin(10), arlatin(11). CONCLUSION Compounds 3, 7~11 are isolated from genus for the first time. |
| Key words: Artemisia myriantha Wall. ex Bess. constituents flavone sesquiterpene lactone |
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