| 引用本文: | 杨庆蕊,王玮.硫酸沙丁胺醇微球缓释片的制备及初步药动学研究[J].中国现代应用药学,2014,31(6):714-717. |
| YANG Qingrui,WANG Wei.Study on Preparation and Pharmacokinetics of Salbutamol Sulfate Microspheres Sustained Release Tablets[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(6):714-717. |
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| 摘要: |
| 目的 探讨硫酸沙丁胺醇微球缓释片的制备方法，并对微球缓释片在家犬体内的药动学进行初步研究。方法 运用喷雾干燥法制备硫酸沙丁胺醇缓释微球，直接压片得到硫酸沙丁胺醇微球缓释片。对微球缓释片和市售普通片进行家犬体内单剂量给药实验，建立了血药浓度测定的高效液相色谱法。结果 普通片和微球缓释片的药动学参数Cmax分别为(155.1±3.4)和(126.7±1.9)ng·mL-1；Tmax分别为(1.5±0.6)和(4.1±0.8)h；t1/2分别为(4.12±0.93)和(5.73±0.64)h，相对生物利用度为109.7%。结论 硫酸沙丁胺醇微球缓释片具有缓释效果。 |
| 关键词: 硫酸沙丁胺醇 微球 缓释片 生物利用度 |
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| Study on Preparation and Pharmacokinetics of Salbutamol Sulfate Microspheres Sustained Release Tablets |
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YANG Qingrui1, WANG Wei2
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1.Pharmacy Department of Xinxiang Central Hospital, Xinxiang 453000, China;2.Pharmaceutical College of Henan University, Kaifeng 475004, China
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| Abstract: |
| OBJECTIVE To explore the methods to prepare salbutamol sulfate microspheres sustained-release tablets, and study its pharmacokinetics and relative bioavailability in dogs. METHODS Salbutamol sulfate sustained release microspheres were prepared of by spray drying method, and then direct tabletting. The microspheres sustained release tablets and commercial tablets in dogs were performed single dose experiments by HPLC. RESULTS The pharmacokinetic parameters for the single dose of commercial tablets and tested tablets were Cmax (155.1±3.4) and (126.7±1.9)ng·mL-1, Tmax(1.5±0.6) and (4.1±0.8)h; t1/2 (4.12±0.93) and (5.73±0.64)h, the relative bioavailability was 109.7%. CONCLUSION Salbutamol sulfate microspheres sustained-release tablets is sustained-release preparation. |
| Key words: salbutamol sulfate microsphere sustained-release tablets bioavailability |
