| 引用本文: | 李培武,伏旭,傅仲学.内皮素受体及其受体拮抗剂在心血管疾病中的作用[J].中国现代应用药学,2014,31(3):376-380. |
| LI Peiwu,FU Xu,FU Zhongxue.Effect of Endothelin Receptors, Endotheline Receptor Antagonist on Cardiovascular Disease[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(3):376-380. |
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| 摘要: |
| 目的 探讨内皮素受体在心血管疾病(cardiovascular disease，CVD)生理病理中的作用，为内皮素受体拮抗剂的新药合成和发现提供参考。方法 综述了近年来国内外相关报道，并对临床研究和作用机制进行讨论，重点强调了内皮素受体，尤其是ETB受体在不同组织具有不同的病理生理学应答机制，发挥不同生理学作用。结果 内皮素受体在CVD治疗中发挥重要作用。结论 内皮素受体拮抗剂是临床治疗CVD的潜在有效手段。 |
| 关键词: 内皮素受体 内皮素-1 心血管疾病 |
| DOI： |
| 分类号:R543.5 |
| 基金项目:甘肃省技术研究与开发专项计划项目(0709TCYA062) |
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| Effect of Endothelin Receptors, Endotheline Receptor Antagonist on Cardiovascular Disease |
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LI Peiwu1,2, FU Xu2, FU Zhongxue1
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1.Department of General Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China;2.Emergency Center, Lanzhou University Second Hospital, Lanzhou 730030, China
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| Abstract: |
| OBJECTIVE To discuss the role of endothelin receptors in physiological and pathological cardiovascular diseases(CVD), and provide a reference in new drug synthesis and discovery. METHODS According to the correlative reports in recent years, endothelin receptors, especially ETB receptors, and its mechanism and response in the pathophysiology in different organizations were discussed in clinical research. RESULTS Endothelin receptor played an important role in CVD therapy. CONCLUSION Endothelin receptor antagonists have been assumed as potential strategies for the treatment in CVD. |
| Key words: endothelin receptor endothelin-1 cardiovascular disease |
