| 引用本文: | 张杰,黄桂华.多单元调释给药系统在复方制剂中的应用[J].中国现代应用药学,2014,31(3):380-386. |
| ZHANG Jie,HUANG Guihua.Application of Multi-unit Modified Drug Delivery Systems in Compound Preparation[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(3):380-386. |
|
| 摘要: |
| 复方制剂由2种或2种以上的药物组分进行配伍，通过协同、加合作用或拮抗不良反应，与单方制剂比较，疗效更加显著。将多单元调释给药系统应用于复方制剂中，能更灵活地调节释药方案，全方位、多靶点、多环节作用，使药物生物利用度提高，不良反应降低。本研究针对镇痛、抗感染、降糖和降压几种常见复方制剂及中药复方制剂的复方原理作一综述，并重点阐述多单元调释给药系统在复方制剂中应用的优势，以期为复方制剂的临床开发提供新的思路。 |
| 关键词: 多单元给药系统 调释给药系统 复方制剂 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Application of Multi-unit Modified Drug Delivery Systems in Compound Preparation |
|
ZHANG Jie, HUANG Guihua
|
|
School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
|
| Abstract: |
| The compound preparations are composed by two or more pharmaceutical ingredients, which can enhance the drug effect significantly through synergistic and additive effect or being antagonistic to side effect compared with prescribed preparation. The multi-unit modified release drug delivery system was used in compound preparation to flexibly adjust the release program and play an all-round, multi-target and multi-link role to improve drug bioavailability and reduce side effects. In this article, the principles of several common compound preparations such as analgesic, anti-infective, hypoglycemic and antihypertensive drug and traditional Chinese medicine compound preparations were summarized. The advantages of multi-unit modified release drug delivery system applied in the compound preparation were emphasized in order to provide new ideas to the clinical development of compound preparation. |
| Key words: multi-unit release drug delivery system modified release drug delivery system compound preparation |
