落新妇苷固体分散体在大鼠体内的药动学研究

胡凯; 扈荣; 许鹏庆; 白海波; 傅旭春<sup>*</sup>

引用本文:	胡凯,扈荣,许鹏庆,白海波,傅旭春.落新妇苷固体分散体在大鼠体内的药动学研究[J].中国现代应用药学,2013,30(10):1102-1104.
	HU Kai,HU Rong,XU Pengqing,BAI Haibo,FU Xuchun.Study on Pharmacokinetics of Astilbin Solid Dispersion in Rat[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(10):1102-1104.

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落新妇苷固体分散体在大鼠体内的药动学研究
胡凯^1,2, 扈荣², 许鹏庆², 白海波², 傅旭春³
1.浙江大学药学院，杭州 310058;2.杭州华东医药集团生物工程研究所有限公司，杭州 310011;3.浙江大学城市学院药物研究所，杭州 310015

摘要:

目的研究大鼠口服落新妇苷固体分散体后的药动学参数。方法采用HPLC测定大鼠口服落新妇苷固体分散体后血浆中的落新妇苷血药浓度。用Kinetica软件计算药动学参数。结果落新妇苷在大鼠体内的药动学过程符合二室模型。AUC_{0-480 min}为(1.98±0.60)mmol·min·L^-1。结论将落新妇苷制成固体分散体可以显著提高其生物利用度。

关键词: 落新妇苷固体分散体药动学生物利用度

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Study on Pharmacokinetics of Astilbin Solid Dispersion in Rat

HU Kai^1,2, HU Rong², XU Pengqing², BAI Haibo², FU Xuchun³

1.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China;2.Hangzhou Huadong Medicine Group Biotechnology R&D Institute Co., Ltd, Hangzhou 310011, China;3.Institute of Materia Medica, Zhejiang University City College, Hangzhou 310015, China

Abstract:

OBJECTIVE To study the pharmacokinetics of astilbin solid dispersion in rat. METHODS HPLC was used to determine the astilbin concentration in the plasma of rats. The pharmacokinetic parameters were calculated with Kinetica software. RESULTS After the rats were orally administrated with astilbin solide dispersions, the pharmacokinetic process of astilbin in rats was found to be consistent with the two-compartment model. The AUC_{0-480 min} was (1.98±0.60)mmol·min·L^-1. CONCLUSION The astilbin in solid dispersion can greatly improve its bioavailability in rat.

Key words: astilbin solid dispersion pharmacokinetics bioavailability