| 引用本文: | 赵杰,李华侃.醌茜素荷移分光光度法测定盐酸伊托必利[J].中国现代应用药学,2013,30(10):1123-1125. |
| ZHAO Jie,LI Huakan.Spectrophotometry Determination of Itopride Hydrochloride Based on Charge-transfer Reaction with Quinalizarin[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(10):1123-1125. |
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| 摘要: |
| 目的 建立测定盐酸伊托必利含量的方法。方法 盐酸伊托必利与醌茜素在碱性条件下可发生电荷转移反应，形成稳定的1∶1型荷移络合物，在最大吸收波长578 nm处测定络合物的吸光度。结果 盐酸伊托必利药物质量浓度在20.0~140.0 mg·L-1内服从比耳定律，相关系数为0.999 1，RSD为0.62%，表观摩尔吸光系数为2.03×103 L·mol-1·cm-1，回收率为99.1%~102.3%。结论 方法准确、简便、快捷，可用于测定片剂中盐酸伊托必利的含量。 |
| 关键词: 盐酸伊托必利 醌茜素 荷移反应 分光光度法 |
| DOI： |
| 分类号:R927. 2 |
| 基金项目: |
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| Spectrophotometry Determination of Itopride Hydrochloride Based on Charge-transfer Reaction with Quinalizarin |
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ZHAO Jie, LI Huakan
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Department of Chemistry, Liaoning Medical College, Jinzhou 121001, China
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| Abstract: |
| OBJECTIVE To establish a method for determination of itopride hydrochloride. METHODS Itopride hydrochloride reacted with quinalizarin to form stable charge transfer complex whose composition ratio is 1∶1 under alkaline conditions and could be determined at 578 nm. RESULTS Beer′s Law is obeyed in the range of 20.0-140.0 mg·L-1 of itopride hydrochloride and the correlation coefficient is 0.999 1. And RSD is 0.62%. The apparent molar absorptivity of the complex is 2.03×103 L·mol-1·cm-1. The recoveries are 99.1%~102.3%. CONCLUSION The method is simple, rapid and accurate, can be used to the determination of itopride hydrochloride in tablets. |
| Key words: itopride hydrochloride quinalizarin charge-transfer reaction spectrophotometry |
