| 引用本文: | 王建,曾红霞,陈悦.罗红霉素晶型分析及与溶解速率、溶出度的关系[J].中国现代应用药学,2013,30(10):1094-1097. |
| WANG Jian,ZENG Hongxia,CHEN Yue.Relationship of Roxithromycin Crystal Types, Dissolution Rates and Dissolution[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(10):1094-1097. |
|
| 摘要: |
| 目的 对罗红霉素的晶型进行分析，并探讨不同晶型对罗红霉素溶解速率、溶出度的影响。方法 晶型分析采用X射线粉末衍射法和红外光谱法，溶解速率和溶出度测定采用转篮法，转速为100 r·min-1。结果 3种罗红霉素的结晶为3种不同的晶型，不同晶型的罗红霉素溶解速率和溶出度有一定差异。结论 为罗红霉素用药的有效性提供了科学依据。 |
| 关键词: 罗红霉素 晶型 溶解速率 溶出度 X射线粉末衍射法 红外光谱法 |
| DOI： |
| 分类号: |
| 基金项目:2012年国家药品评价性抽验项目 |
|
| Relationship of Roxithromycin Crystal Types, Dissolution Rates and Dissolution |
|
WANG Jian1,2, ZENG Hongxia1, CHEN Yue2
|
|
1.Zhejiang University of Technology, Hangzhou 310014, China;2.Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China
|
| Abstract: |
| OBJECTIVE To study the crystal types of roxithromycin, and the relationship of roxithromycin crystal types and its dissolution rate and dissolution. METHODS X-ray powder diffraction and infrared spectroscopy were used in the analysis of crystal types. The dissolutive apparatus was used with 100 r·min-1. RESULTS The result showed that three crystals of roxithromycin were different crystal types, and the dissolution rates and dissolutions of different crystal types had some differences. CONCLUSION The study provids a scientific basis for the effectiveness of roxithromycin. |
| Key words: roxithromycin crystal type dissolution rate dissolution X-ray powder diffraction infrared spectroscopy |
