| 引用本文: | 曾令全,龙万梅,傅洪,魏安宁.丙泊酚的配伍研究[J].中国现代应用药学,2013,30(10):1126-1131. |
| ZENG Lingquan,LONG Wanmei,FU Hong,WEI Anning.Compatibility of Propofol Emulsion[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(10):1126-1131. |
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| 摘要: |
| 目的 考察室温下6 h内，丙泊酚乳剂与利多卡因注射液和/或地塞米松注射液配伍后的稳定性。方法 采用离心分光光度法、苏丹染色实验、电导率测定以及混合液pH值和激光粒度分析等方法来考察丙泊酚(A组)、丙泊酚与利多卡因9∶1混合(B组)、丙泊酚与利多卡因4∶1混合(C组)、丙泊酚与利多卡因及0.5%地塞米松以3∶1∶1的比例混合(D组)的稳定性。结果 室温下6 h内，B、C、D组与A组比较，稳定常数(Ke)值明显增高(P<0.05)。各组未见分层和颜色变化。B组与A组比较，各时点pH值明显降低，具有显著性差异(P<0.05)，D组与B组比较，各时点pH值明显升高(P<0.05)。电导率值为A组
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| 关键词: 丙泊酚乳剂 利多卡因 地塞米松 激光粒度分析 配伍 |
| DOI： |
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| 基金项目:重庆市卫生局医学科研计划项目(2011-2-392) |
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| Compatibility of Propofol Emulsion |
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ZENG Lingquan1, LONG Wanmei2, FU Hong3, WEI Anning4
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1.Department of Anesthesiology, the Thirteenth People’s Hospital of Chongqing, Chongqing 400053, China;2.Pharmacy Division, the Seventh People’s Hospital of Chongqing, Chongqing 400053, China;3.Department of Anesthesiology, Chongqing TCM Hospital, Chongqing 400021, China;4.Department of Anesthesiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
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| Abstract: |
| OBJECTIVE To investigate the compatibility of propofol emulsion combined with lidocaine injection and/or dexamethasone injection. METHODS Centrifugal spectrophotometry, Sudan test, conductivity measuring, pH and laser particle size analysis were used to observe the stability of propofol(group A), propofol and lidocaine mixed by 9∶1(group B), propofol and lidocaine mixed by 4∶1(group C), propofol and lidocaine and dexamethasone mixed by 3∶1∶1(group D) within 6 hours under room temperature. RESULTS The Ke of group B, C, D were significantly increased compared with group A, (P<0.05). Each group showed no stratification and color change. The pH of group B was decreased compared with group A at each time(P<0.05). The conductivity value of group A
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| Key words: propofole mulsion lidocaine dexamethasone laser particle size analysis compatibility |
