| 引用本文: | 张红玉,杨锋,王波波,陈宇.五福饮对荷瘤小鼠抑瘤率和免疫调节作用的影响[J].中国现代应用药学,2013,30(9):949-952. |
| ZHANG Hongyu,YANG Feng,WANG Bobo,CHEN Yu.Effects of Wufu Decoction on Tumor Inhibition Rate and Immune Regulation of Tumor-burdened Mice[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(9):949-952. |
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| 摘要: |
| 目的 观察五福饮对荷S180移植瘤小鼠免疫功能的影响及抑瘤作用。方法 荷瘤小鼠随机分为模型组、环磷酰胺对照组(80 mg·kg-1)，五福饮低、中、高剂量组(分别含生药5.25，10.5，21.0 g·kg-1，相当于人体临床用量的10，20和40倍)及正常对照组。结果 与模型组比较，五福饮高、中2个剂量组均可明显提高荷瘤小鼠ConA诱导的脾淋巴细胞转化、小鼠NK细胞活性和血清IFN-γ、TNF-α水平，差异均有统计学意义(P<0.05)。五福饮各组对S180移植瘤抑制率为11%~16%，但与模型组比较无明显差异(P＞0.05)。结论 五福饮对S180移植瘤的抑制作用不显著，但可增强荷S180移植瘤小鼠的免疫功能。 |
| 关键词: 五福饮 调节免疫 抗肿瘤 |
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| Effects of Wufu Decoction on Tumor Inhibition Rate and Immune Regulation of Tumor-burdened Mice |
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ZHANG Hongyu1, YANG Feng2, WANG Bobo2, CHEN Yu2
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1.Pharmacy Department, Hangzhou Cancer Hospital，Hangzhou 310002, China;2.Zhejiang Institute of Traditional Chinese Medicine, Hangzhou 310007, China
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| Abstract: |
| OBJECTIVE To observe the effects of Wufu decoction on the immune regulation and tumor inhibition rate of tumor-burdened mice. METHODS Mice were randomly divided into six groups: model group, cyclophosphamide group, low, middle and high dose of Wufu decoction groups (5.25, 10.5, 21.0 g·kg-1, equivalent to 10, 20 and 40 times of human clinical dosage), normal control group. RESULTS High and middle dose of Wufu decoction groups could significantly increase T lymphocyte transformations capacity induced by ConA(P<0.05), improve NK cell activity(P<0.05), and raise serum IFN-γ, TNF-α level(P<0.05). The tumor inhibition rates of three Wufu decoction groups were 11%-16%, but had no obvious difference compared with model group(P>0.05). CONCLUSION Wufu decoction has no significant inhibition to S180 transplantation tumor, but can significantly improve the immunological function of tumor-burdened mice. |
| Key words: Wufu decoction immune regulation antitumor |
