| 引用本文: | 潘昕,黄莹,朱春娥,何嘉懿,覃玲珍,张日亘,吴传斌.混合膜材及添加剂对包衣膜性质的影响[J].中国现代应用药学,2013,30(6):619-623. |
| PAN Xin,HUANG Ying,ZHU Chun’e,HE Jiayi,QIN Linzhen,ZHANG Xuan,WU Chuanbin.Effect of Coating Materials and Additives on Properties of Combination[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(6):619-623. |
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| 摘要: |
| 目的 制备肠溶性包衣膜，考察混合膜材以及添加剂对膜材性质的影响。方法 采用平面铸膜法制备Eudragit NE 30D/L 30D-55及Eudragit FS 30D/L 30D-55游离膜，并以膜的透湿性、机械性能为指标，考察膜材比例及添加剂[增塑剂柠檬酸三乙酯(TEC)、抗黏剂单硬脂酸甘油酯(GMS)、乳化剂吐温80 (Tween-80)]对游离膜的影响。结果 Eudragit NE 30D及Eudragit FS 30D的加入能够增加Eudragit L 30D-55膜材的延展性、弹性和耐撞击负载的能力，同时也会减小膜材的强度、增加其透湿性。Eudragit L 30D-55与Eudragit NE 30D的混合膜材透湿性较大，对于湿度敏感性药物，应尽量避免选择透湿性大的包衣膜材。TEC和Tween-80的加入可改善膜材的柔韧性和弹性，降低膜材的强度，同时，TEC的加入可以增加膜材的透湿性，而GMS对膜材各项机械性质和透湿性影响不大。结论 通过简单的调节混合膜材的种类、比例、添加剂的用量可以制得符合要求的肠溶游离膜。 |
| 关键词: Eudragit NE 30 D Eudragit FS 30D Eudragit L 30D-55 透湿性 机械性质 丙烯酸树脂 |
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| 基金项目:国家自然科学基金青年科学基金(81202476) |
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| Effect of Coating Materials and Additives on Properties of Combination |
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PAN Xin1, HUANG Ying1, ZHU Chun’e1, HE Jiayi2, QIN Linzhen1, ZHANG Xuan1, WU Chuanbin1,3
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1.School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China;2.College of Life Science, Nanjing University, Nanjing 210046, China;3.Research and Development Center of Pharmaceutical Engineering, Sun Yat-sen University, Guangzhou 510006, China
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| Abstract: |
| OBJECTIVE To prepare enteric films and investigate the effect of coating materials and additives on films’ properties. METHODS Free films of Eudragit NE 30D/L 30D-55 and Eudragit FS 30D/L 30D-55 were prepared by plane casting method. The films component and additives, such as plasticizer (triethyl citrate, TEC), antisticking agent (glyceryl monostearate, GMS) and emulsifier (Tween-80) were investigated for films permeability and mechanical properties. RESULTS The addition of Eudragit NE 30D or Eudragit FS 30D to Eudragit L 30D-55 could enhance the ductility, flexibility and impact resistance ability, but reduce the intensity and increase the moisture permeability of the combination films. The combination films prepared by Eudragit NE 30D showed high moisture permeability, indicating the films were inappropriate for humidity sensitive drugs. The addictive of TEC and Tween-80 could improve the flexibility and elasticity, and reduce the intensity of the combination films. TEC could increase the moisture permeability, and the ratio of GMS had little effect on the casted films permeability and mechanical properties. CONCLUSION Enteric combination films can be prepared by simply adjusting the kinds and amounts of film component and additives to meet the manufacture requirements. |
| Key words: Eudragit NE 30 D Eudragit FS 30D Eudragit L 30D-55 moisture permeability mechanical property acrylic resin |
