| 引用本文: | 倪佳婷,董晶,胡文君,杜文婷.N-杂环卡宾催化的成环反应研究进展[J].中国现代应用药学,2013,30(5):558-564. |
| NI Jiating,DONG Jing,HU Wenjun,DU Wenting.Process in N-Heterocyclic Carbene-Catalyzed Annulation Reactions[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(5):558-564. |
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| 摘要: |
| 目的 介绍N-杂环卡宾催化的成环反应研究进展。方法 综合国内外报道的文献，阐述N-杂环卡宾催化的成环反应。结果 列出了N-杂环卡宾催化的分子内Stetter反应、亲核取代反应、环加成反应和串联反应等成环方法，重点分析了N-杂环卡宾催化的[4+2]，[3+2]，[2+2]和[3+3]环加成合成法。结论 N-杂环卡宾催化成环反应的发展在有机合成方法学中为高效成环提供了新的途径和策略。 |
| 关键词: N-杂环卡宾(NHC) 成环反应 催化 |
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| 基金项目:国家自然科学基金项目(21002026)；2012年浙江省大学生科技创新活动计划(新苗人才计划2012R434006)；浙江医学高等专科学校博士启动基金项目(No.2011B01) |
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| Process in N-Heterocyclic Carbene-Catalyzed Annulation Reactions |
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NI Jiating, DONG Jing, HU Wenjun, DU Wenting
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Department of Pharmacy, Zhejiang Medical College, Hangzhou 310053, China
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| Abstract: |
| OBJECTIVE To introduce the process in N-heterocyclic carbene-catalyzed annulation reactions. METHODS To review both domestic and international published reports regarding N-heterocyclic carbene-catalyzed annulation reactions. RESULTS To make a list of N-heterocyclic carbene-catalyzed annulation reactions of intramolecular Stetter reaction, nucleophilic substitution reaction, cycloaddition and tandem reaction and to analyze N-heterocyclic carbene-catalyzed [4+2], [3+2], [2+2] and [3+3] cycloaddition specially. CONCLUSION The development of the N-heterocyclic carbene-catalyzed annulation reactions provides us new ways and strategies for efficient annulation. |
| Key words: N-heterocyclic carbene (NHC) annulation reactions catalyze |
