| 引用本文: | 虞希晨,寿军,周权.重组人血管内皮抑制素在静脉输液中的稳定性研究[J].中国现代应用药学,2013,30(12):1299-1302. |
| YU Xicheng,,SHOU Jun,,ZHOU Quan.Stability Study of Endostatin in PVC, Non-PVC Infusion Bags and Drug Infusion Pumps[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(12):1299-1302. |
|
| 摘要: |
| 目的 考察重组人血管内皮抑制素注射液(恩度)在静脉输液中的稳定性，为临床合理用药提供依据。方法 模拟临床给药剂量和给药时间，采用高效液相色谱法测定重组人血管内皮抑制素注射液在聚氯乙烯(PVC)输液袋、非PVC输液袋及全自动注药泵中不同温度、不同时间点的药物浓度。结果 在25 ℃或37 ℃下，重组人血管内皮抑制素注射液在PVC和非PVC氯化钠输液中至少保持稳定4 h，在全自动注药泵中48 h内保持稳定。结论 在临床实践中，重组人血管内皮抑制素注射液以PVC和非PVC材质的0.9%氯化钠注射液500 mL静脉点滴2 h或全自动注药泵(250 mL)恒速给药24 h，从药品稳定性角度讲是可行的。 |
| 关键词: 重组人血管内皮抑制素 稳定性 PVC输液袋 非PVC输液袋 全自动注药泵 |
| DOI： |
| 分类号: |
| 基金项目:浙江大学科研项目(H20101641) |
|
| Stability Study of Endostatin in PVC, Non-PVC Infusion Bags and Drug Infusion Pumps |
|
YU Xicheng,, SHOU Jun,, ZHOU Quan
|
|
Department of Pharmacy, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
|
| Abstract: |
| OBJECTIVE To investigate the stability of endostatin in PVC infusion bags, non-PVC infusion bags and drug infusion pumps. METHODS In a simulated clinical situation, endostatin was undergone appropriate dilution with 0.9% sodium chloride injection in PVC infusion bags, non-PVC infusion bags or drug infusion pumps. Then high-performance liquid chromatography (HPLC) was employed to determine endostatin concentrations at 0, 1, 2, 4 h or 0, 4, 8, 16, 24 h under 25 ℃ or 37 ℃. RESULTS Endostatin could keep stable in PVC infusion bags or non-PVC infusion bags for at least 4 h, and remained stable for 48 h in drug infusion pumps under 25 ℃ or 37 ℃. CONCLUSION In clinical practice, it is appropriate to administer endostatin by intravenous dripping or via automatic infusion pumps from the perspective of drug stability. |
| Key words: Endostatin stability PVC infusion bags non-PVC infusion bags drug infusion pumps |
